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Relationship between cytokine levels in serum and gingival crevicular fluid (GCF) in pregnant women

机译：孕妇血清中细胞因子水平与龈沟液（GCF）的关系

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Background: Periodontal disease has been linked to systemic diseases/disorders and a low-grade systemic inflammatory status originated from periodontitis has been proposed as a possible explanation for this association. This study evaluates the relationship, early in pregnancy, between gingival crevicular fluid (GCF) and serum levels of a panel of cytokines that have been implicated in PTB and periodontal disease. Methods: One hundred pregnant women aged 18-35. years old with a gestational age up to 20. weeks were included (mean ± SD gestational age:16.1 ± 3.5. weeks). Four periodontal sites per subject were randomly selected for GCF collection. Serum and GCF levels of IL-1β, IL-6, IL-8, IL-10, IL-12p70 and TNF-α were analyzed using a cytometric bead array. Regression and correlation analyses were used to assess the relationship between serum and GCF cytokine levels. Results: Participants had widespread periodontal inflammation but limited periodontal destruction. Cytokine levels were significantly higher in GCF than serum for all cytokines but IL-10. GCF levels had small but significant effect on serum levels for IL-10 (β= 0.34 ± 0.09, p< 0.01), IL-12p70 (β= 0.48 ± 0.08, p< 0.01) and TNF-α (β= 0.29 ± 0.09, p< 0.01). Periodontal probing depth and bleeding on probing were significantly associated with GCF levels for IL-1β, IL-6 and IL-8; however, they had negligible effect on serum cytokine levels. Correlation between GCF and serum levels was non-significant, except for IL-12p70, which showed a significant but small correlation between the two sources (r= 0.32, p= 0.001). Conclusions: GCF cytokine levels were not strongly associated with serum cytokine levels in pregnant women with widespread periodontal inflammation but limited periodontal destruction.
机译：背景：牙周疾病已与全身性疾病/疾病相关，并且有人提出源自牙周炎的低度全身性炎症状态可能是这种关联的一种解释。这项研究评估了妊娠早期牙龈沟液（GCF）与一组涉及PTB和牙周疾病的细胞因子的血清水平之间的关系。方法：一百名18-35岁的孕妇。胎龄不超过20岁，不超过20周（平均±SD胎龄：16.1±3.5。周）。每个受试者随机选择四个牙周部位进行GCF收集。使用细胞计数微珠阵列分析IL-1β，IL-6，IL-8，IL-10，IL-12p70和TNF-α的血清和GCF水平。回归和相关分析用于评估血清和GCF细胞因子水平之间的关系。结果：参与者牙周炎广泛，但牙周破坏有限。除IL-10外，GCF中所有细胞因子的细胞因子水平均显着高于血清。 GCF水平对IL-10（β= 0.34±0.09，p <0.01），IL-12p70（β= 0.48±0.08，p <0.01）和TNF-α（β= 0.29±0.09）的血清水平影响很小但很明显，p ＜0.01）。牙周探测深度和探测时出血与IL-1β，IL-6和IL-8的GCF水平显着相关。然而，它们对血清细胞因子水平的影响可忽略不计。除IL-12p70外，GCF与血清水平之间的相关性不显着，IL-12p70在两种来源之间显示出显着但很小的相关性（r = 0.32，p = 0.001）。结论：在牙周炎症广泛但牙周破坏有限的孕妇中，GCF细胞因子水平与血清​​细胞因子水平没有显着相关。

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