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首页> 外文期刊>Cytokine >Clinical significance of plasma CD146 and P-selectin in patients with type 2 diabetic nephropathy
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Clinical significance of plasma CD146 and P-selectin in patients with type 2 diabetic nephropathy

机译：2型糖尿病肾病患者血浆CD146和P-选择素的临床意义

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Objective: To investigate the levels of plasma CD146 and P-selectin in patients with type 2 diabetic nephropathy at different stages. Methods: A total of 80 patients with type 2 diabetes mellitus were enrolled in the present study. According to 24. h urinary albumin excretion ratio and renal function, they were further divided into group of diabetes without microalbuminuria (DN0, . n=. 20), microalbuminuria group (DN1, . n=. 20), macroalbuminuria group (DN2, . n=. 20) and renal insufficiency group (DN3, . n=. 20). Another 20 healthy subjects were enrolled as control group (non-DM). Plasma CD146 and P-selectin were measured by ELISA. Results: Plasma CD146 and P-selectin were significantly increased in patients with type 2 diabetes with microalbuminuria (DN1) compared with health control (CD146: 415.3. ±. 29.0 vs. 243.5. ±. 14.7. ng/ml, . P<. 0.05; P-selectin: 66.8. ±. 3.4 vs. 45.3. ±. 2.7. ng/ml, . P<. 0.001). With the development of diabetic nephropathy, both plasma CD146 and P-selectin level progressively rise, with the highest levels in patients with significant renal insufficiency (DN3: 515.9. ±. 36.9 and 81.5. ±. 5.1. ng/ml respectively, . P<. 0.001). Moreover, the increase in CD146 is positively co-related to the rise of P-selectin in patients with type 2 diabetes. Conclusion: Expression of CD146 and P-selectin in patients with type 2 diabetes is elevated, and they are positively correlated with severity of diabetic nephropathy.
机译：目的：探讨不同阶段2型糖尿病肾病患者血浆CD146和P-选择素的水平。方法：本研究共纳入80例2型糖尿病患者。根据24 h尿白蛋白排泄率和肾功能，将它们进一步分为无微量白蛋白尿的糖尿病组（DN0，n = 20），微量白蛋白尿组（DN1，n = 20），巨白蛋白尿组（DN2，n = 20）。 （n = 20）和肾功能不全组（DN3，n = 20）。将另外20名健康受试者作为对照组（非DM）。通过ELISA测量血浆CD146和P-选择蛋白。结果：与健康对照组相比，患有微量白蛋白尿（DN1）的2型糖尿病患者血浆CD146和P-选择素显着增加（CD146：415.3。±。29.0 vs. 243.5。±。14.7。ng / ml，。 0.05; P-选择素：66.8±3.4与45.3。±2.7 ng / ml ，. P <。0.001）。随着糖尿病性肾病的发展，血浆CD146和P-选择素水平均逐渐升高，在患有严重肾功能不全的患者中水平最高（分别为DN3：515.9。±。36.9和81.5。±。5.1。ng / ml，。P <.0.001）。此外，在2型糖尿病患者中，CD146的增加与P-选择素的增加呈正相关。结论：2型糖尿病患者CD146和P-选择素的表达升高，与糖尿病肾病的严重程度呈正相关。

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