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首页> 外文期刊>Biotechnology Advances: An International Review Journal >Algal metabolites: An inevitable substitute for antibiotics
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Algal metabolites: An inevitable substitute for antibiotics

机译：藻类代谢物：抗生素的不可避免的替代品

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Antibiotic resistance is rising at a pace that is difficult to cope with; circumvention of this issue requires fast and efficient alternatives to conventional antibiotics. Algae inhabit a wide span of ecosystems, which contributes to their ability to synthesize diverse classes of highly active biogenic metabolites. Here, for the first time, we reviewed all possible algal metabolites with broad spectra antibacterial activity against pathogenic bacteria, including antibiotic-resistant strains, and categorized different metabolites of both freshwater and marine algae, linking them on the basis of their target sites and mechanistic actions along with their probable nanoconjugates. Algae can be considered a boon for novel drug discovery in the era of antibiotic resistance, as various algal primary and secondary metabolites possess potential antibacterial properties. The diversity of these metabolites from indigenous sources provides a promising gateway enabling researchers and pharmaceutical companies to develop novel nontoxic, cost-effective and highly efficient antibacterial medicines.
机译：抗生素耐药性以难以应对的速度升高;这种问题的规避需要快速和有效的常规抗生素的替代品。藻类居住在广泛的生态系统中，这有助于综合各种高活性生物代谢物的能力。我们在此，我们首次审查了所有可能的藻类代谢物，具有广泛的抗菌菌免受致病菌的抗菌活性，包括抗生素抗菌菌株，并根据其靶位点和机械组成它们的淡水和海藻的不同代谢物。行动与他们可能的纳米缀合物一起。藻类可以被认为是一种在抗生素抗性时代的新药发现中的植物，因为各种藻类初级和次级代谢物具有潜在的抗菌性质。来自土着来源的这些代谢物的多样性提供了一个有前途的网关，使研究人员和制药公司能够开发新的无毒，具有成本效益和高效的抗菌药物。

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