Protein synthesis-dependent and -independent induction of p69 2'-5'-oligoadenylate synthetase by interferon-alpha.

Yu F; Floyd Smith-G

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Protein synthesis-dependent and -independent induction of p69 2'-5'-oligoadenylate synthetase by interferon-alpha.

机译：p69 2'-5'-寡腺苷酸合成酶的蛋白质合成依赖性和非依赖性诱导。

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The 2'-5'-oligoadenylate (2-5A) synthetases are a family of interferon-alpha (IFN-alpha) inducible enzymes that block viral replication by activating a latent endonuclease during viral infections. In Ramos cells, induction of mRNAs for the intermediate isoform of 2-5A synthetase (p69) requires five-fold higher IFN-alpha than is required for induction of the small isoform (p40). The p40 and p69 isoforms are similarly induced between 1 and 24 h with maximal induction at 8 h. At 48 h, however, p69 is more strongly induced than p40. Induction of p69 and p40 between 1 and 24 h is protein synthesis independent whereas at 48 h, p69 induction becomes dependent on protein synthesis. Initial induction of both isoforms requires tyrosine kinase activation and is enhanced by activation of a separate signalling pathway by the tumour promoter, 12-0-tetradecanoyl phorbol-13-acetate (TPA). These data suggest that induction of the p40 is predominantly protein synthesis independent, whereas p69 induction occurs in two phases, an initial protein synthesis independent phase and a delayed protein synthesis dependent phase. Copyright 1999 Academic Press.

机译：2'-5'-寡腺苷酸（2-5A）合成酶是干扰素-α（IFN-α）诱导型酶家族，可通过在病毒感染过程中激活潜在的核酸内切酶来阻断病毒复制。在Ramos细胞中，诱导2-5A合成酶的中间同工型（p69）的mRNA需要比诱导小同工型（p40）高五倍的IFN-α。 p40和p69同工型在1至24 h之间类似地被诱导，最大诱导在8 h时发生。然而，在48 h时，p69比p40更强烈地被诱导。在1至24小时之间诱导p69和p40与蛋白质合成无关，而在48小时时，p69诱导变得依赖于蛋白质合成。两种同工型的初始诱导都需要酪氨酸激酶激活，并通过肿瘤启动子12-0-十四烷酰基佛波醇13-乙酸酯（TPA）激活单独的信号传导途径而增强。这些数据表明，p40的诱导主要与蛋白质合成无关，而p69的诱导分为两个阶段，即初始蛋白质合成非依赖性阶段和延迟蛋白质合成依赖性阶段。版权所有1999，学术出版社。

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《Cytokine》 |1999年第10期|共7页
作者
Yu F; Floyd Smith-G;
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正文语种 eng
中图分类细胞生物学;
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Interferon-alpha; Proteins; Trans Activation Genetics drug effects; 2'; 5'-Oligoadenylate Synthetase; 干扰素α; 蛋白质类; 2'; 5'-寡腺苷酸合成酶;

机译：Interferon-alpha;Proteins;Trans Activation Genetics drug effects;2';5'-Oligoadenylate Synthetase;干扰素α;蛋白质类;2';5'-寡腺苷酸合成酶;

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1. Protein synthesis-dependent and -independent induction of p69 2'-5'-oligoadenylate synthetase by interferon-alpha. [J] . Yu F, Floyd Smith-G Cytokine . 1999,第10期

机译：p69 2'-5'-寡腺苷酸合成酶的蛋白质合成依赖性和非依赖性诱导。
2. p59OASL, a 2'-5' oligoadenylate synthetase like protein: a novel human gene related to the 2'-5' oligoadenylate synthetase family. [J] . Hartmann R, Olsen HS, Widder S, Nucleic Acids Research . 1998,第18期

机译：p59OASL，一种2'-5'寡腺苷酸合成酶样蛋白：与2'-5'寡腺苷酸合成酶家族有关的新型人类基因。
3. p59OASL, a 2′–5′ oligoadenylate synthetase like protein: a novel human gene related to the 2′–5′ oligoadenylate synthetase family [J] . Henrik Steen Olsen, Just Justesen, René J?rgensen, Nucleic acids research . 1998,第18期

机译：p59OASL，一种2'-5'寡腺苷酸合成酶样蛋白：与2'-5'寡腺苷酸合成酶家族有关的新型人类基因
4. Lamin A (LmnA)-induced conformational changes of AIMP3 (aminoacyl-tRNA synthetases-interacting multifunctional protein 3) revealed by H/D Exchange FT-ICR MS [C] . Yeqing Tao, Pengfei Fang, Nicolas L. Young, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：Lamin A（LMNA） - 由H / D Exchange FT-ICR MS揭示的AIMP3（氨基酰基-TRNA合成酶 - 相互作用蛋白3）的构象变化
5. Structure-based design of mutant proteins: I. Molecular docking studies of amino acid binding to wild-type aminoacyl-tRNA synthetases. II. Structure-based design of mutant aminoacyl-tRNA synthetases for non-natural amino acid incorporation. [D] . Zhang, Deqiang. 2003

机译：基于结构的突变蛋白设计：I.氨基酸与野生型氨酰基tRNA合成酶结合的分子对接研究。二。非天然氨基酸掺入的突变型氨酰基-tRNA合成酶的基于结构的设计。
6. Protein binding to the interferon response enhancer correlates with interferon induction of 2-5-oligoadenylate synthetase in normal and interferon-resistant Friend cells. [O] . E M Coccia, D Vaiman, J Raber, 1991

机译：与干扰素应答增强剂结合的蛋白质与正常和抗干扰素的Friend细胞中2-5-寡腺苷酸合成酶的干扰素诱导相关。
7. The NS5A protein of Hepatitis C Virus Interacts with 2', 5'-Oligoadenylate Synthetase and Inhibits Antiviral Activity of Interferon in an ISDR-Independent, PKR-Independent Manner [O] . 田口高志 2003

机译：丙型肝炎病毒的NS5A蛋白与2'，5'-寡腺苷酸合成酶相互作用，并以不依赖ISDR，不依赖PKR的方式抑制干扰素的抗病毒活性
8. Formation of Tubuloreticular Inclusions in Human Lymphoma Cells Compared to the Induction of 2'-5'-Oligoadenylate Synthetase by Leucocyte Interferon in Dose-Effect and Kinetic Studies [R] . Grimley, P. M., Rutherford, M. N., Kang, Y. H., 1984

机译：与白细胞干扰素诱导2'-5'-寡腺苷酸合成酶的剂量效应和动力学研究相比，人淋巴瘤细胞中的管状包涵体的形成

Protein synthesis-dependent and -independent induction of p69 2'-5'-oligoadenylate synthetase by interferon-alpha.

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