IL-6 promoter is modulated by the 24 kDa FGF-2 isoform fused to the hormone binding domain of the oestrogen receptor.

Delrieu I; Chinestra P; Delassus F; Bayard F; Prats H; Faye JC

首页> 外文期刊>Cytokine >IL-6 promoter is modulated by the 24 kDa FGF-2 isoform fused to the hormone binding domain of the oestrogen receptor.

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IL-6 promoter is modulated by the 24 kDa FGF-2 isoform fused to the hormone binding domain of the oestrogen receptor.

机译：IL-6启动子受到与雌激素受体激素结合结构域融合的24 kDa FGF-2同工型的调节。

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Fusion proteins consisting of the 24 kDa nuclear form of basic fibroblast growth factor (FGF-2), associated with the hormone binding domain of oestrogen receptor (HBD), convey oestrogen inducibility to FGF-2. When stable HBD-FGF-2 HeLa cell lines were transiently transfected with an interleukin 6 (IL-6) construct, the IL-6 promoter activity was downregulated by the addition of oestradiol. Moreover, in these cell lines, the function of the FGF-2 nuclear localisation sequence was abolished by its fusion to HBD, while addition of oestradiol restored the location of the chimera to the nucleus. Copyright 2000 Academic Press.

机译：融合蛋白由碱性成纤维细胞生长因子（FGF-2）的24 kDa核形式组成，与雌激素受体（HBD）的激素结合域相关，可将雌激素诱导为FGF-2。当用白介素6（IL-6）构建体瞬时转染稳定的HBD-FGF-2 HeLa细胞系时，通过添加雌二醇可下调IL-6启动子的活性。此外，在这些细胞系中，FGF-2核定位序列的功能由于与HBD融合而被废除了，而雌二醇的添加则恢复了嵌合体在细胞核中的位置。版权所有2000学术出版社。

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《Cytokine》 |2000年第7期|共5页
作者
Delrieu I; Chinestra P; Delassus F; Bayard F; Prats H; Faye JC;
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正文语种 eng
中图分类细胞生物学;
关键词
Down Regulation Physiology; Estrogens; Fibroblast Growth Factor; Basic; Interleukin-6; 雌激素类; 成纤维细胞生长因子; 碱性; 白细胞介素6; 受体; 雌激素;

机译：Down Regulation Physiology;Estrogens;Fibroblast Growth Factor;Basic;Interleukin-6;雌激素类;成纤维细胞生长因子;碱性;白细胞介素6;受体;雌激素;

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专利

1. IL-6 promoter is modulated by the 24 kDa FGF-2 isoform fused to the hormone binding domain of the oestrogen receptor. [J] . Delrieu I, Chinestra P, Delassus F, Cytokine . 2000,第7期

机译：IL-6启动子受到与雌激素受体激素结合结构域融合的24 kDa FGF-2同工型的调节。
2. Isoform Specificity for Oestrogen Receptor and Thyroid Hormone Receptor Genes and Their Interactions on the NR2D Gene Promoter. [J] . Vasudevan N, Inoue S, Pfaff D Journal of neuroendocrinology . 2002,第10期

机译：雌激素受体和甲状腺激素受体基因的同工型特异性及其与NR2D基因启动子的相互作用。
3. Inhibition of interleukin-6 promoter activity by the 24 kDa isoform of fibroblast growth factor-2 in HeLa cells. [J] . Delrieu I, Faye JC, Bayard F, The Biochemical Journal . 1999,第Pta1期

机译：HeLa细胞中成纤维细胞生长因子2的24 kDa亚型对白介素6启动子活性的抑制。
4. Analysis of chloride-binding domains of the extrinsic 12-kDa protein by proteolysis and directed mutagenesis [C] . A. Okumura, H. Ohta, K. Kamino, International Congress on Photosynthesis . 2001

机译：通过蛋白水解和定向诱变分析外部12-KDA蛋白的氯化物结合结构域
5. Identification of the hormone contact domains and early signaling events of the human parathyroid hormone 1 (hPTH1) receptor. [D] . Adams, Amy Erin. 2000

机译：鉴定人类甲状旁腺激素1（hPTH1）受体的激素接触域和早期信号事件。
6. Localisation of the oestradiol-binding and putative DNA-binding domains of the human oestrogen receptor. [O] . V Kumar, S Green, A Staub, 1986

机译：人雌激素受体的雌二醇结合和推定的DNA结合结构域的定位。
7. Overexpression of the FGF-2 24-kDa isoform up-regulates IL-6 transcription in NIH-3T3 cells [O] . Delrieu Isabelle, Arnaud Emmanuelle, Ferjoux Géraldine, 1998

机译：FGF-2 24-kDa亚型的过表达上调NIH-3T3细胞中的IL-6转录

IL-6 promoter is modulated by the 24 kDa FGF-2 isoform fused to the hormone binding domain of the oestrogen receptor.

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