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首页> 外文期刊>Cytokine >Circulating transforming growth factor beta(1) as an indicator of hepatic function impairment in liver cirrhosis.
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Circulating transforming growth factor beta(1) as an indicator of hepatic function impairment in liver cirrhosis.

机译：循环转化生长因子β（1）作为肝硬化肝功能损害的指标。

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In the liver, transforming growth factor (TGF) -beta(1)is primarily responsible for activation of fat-storing cells, which are the main source of extracellular matrix proteins. Their deposition play a key role in the development of liver cirrhosis. The aim of this study was to evaluate plasma TGF-beta(1)in patients with different stages of liver cirrhosis and its possible use as an indicator of liver function impairment. TGF-beta(1)was measured in the plasma of 40 patients with liver cirrhosis. To estimate possible effect of liver insufficiency on plasma TGF-beta(1), patients were divided into three groups: A, B and C, univocal with Child-Pugh classes. Normal values were collected from 13 healthy volunteers. Liver cirrhosis resulted in a significant increase of plasma concentration of TGF-beta(1)(39.3+/-3.8 ng/ml), which doubled normal values (18.3+/-1.6 ng/ml). The highest concentrations were observed in alcoholic patients (44.4+/-4.7 ng/ml). TGF-beta(1)level increased depending on the degree of liver insufficiency, demonstrated by a significant positive correlation with Child-Pugh score (r=0.591). Values in group A were similar to normal, but were significantly elevated in groups B and C. These findings suggest possible use of plasma TGF-beta(1)measurement as an indicator of liver function impairment and possible marker of hepatic fibrosis progression in cirrhotic patients. Copyright 2000 Academic Press.
机译：在肝脏中，转化生长因子（TGF）-beta（1）主要负责储脂细胞的活化，这是细胞外基质蛋白的主要来源。它们的沉积在肝硬化的发展中起关键作用。这项研究的目的是评估不同肝硬化阶段患者的血浆TGF-beta（1）及其可能用作肝功能损害的指标。在40例肝硬化患者的血浆中测定了TGF-beta（1）。为了估计肝功能不全对血浆TGF-beta（1）的可能影响，将患者分为三组：A，B和C，Child-Pugh类明确。从13名健康志愿者中收集正常值。肝硬化导致血浆TGF-β（1）浓度显着增加（39.3 +/- 3.8 ng / ml），是正常值（18.3 +/- 1.6 ng / ml）的两倍。在酒精中毒患者中观察到最高浓度（44.4 +/- 4.7 ng / ml）。 TGF-β（1）水平根据肝功能不全的程度而增加，这与Child-Pugh得分呈显着正相关（r = 0.591）。 A组的值与正常值相似，但B和C组中的值显着升高。这些发现表明，可能使用血浆TGF-β（1）测量作为肝硬化患者肝功能损害的指标和肝纤维化进展的可能标志。版权所有2000学术出版社。

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