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首页> 外文期刊>Cytokine >Circulating vascular endothelial growth factor and its soluble receptors in patients with liver cirrhosis: possible association with hepatic function impairment.
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Circulating vascular endothelial growth factor and its soluble receptors in patients with liver cirrhosis: possible association with hepatic function impairment.

机译:肝硬化患者的循环血管内皮生长因子及其可溶性受体:可能与肝功能损害相关。

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Recent studies provided in vivo evidences of an increased angiogenesis in animal model of portal hypertension and cirrhosis which was linked to increased expression of vascular endothelial growth factor. The aim of study was to evaluate the plasma concentration of VEGF and its receptors in liver cirrhosis and the possible association with the degree of liver insufficiency. Methods. Vascular endothelial growth factor (VEGF) and its soluble receptors: sVEGF-R1, sVEGF-R2 were measured in plasma of 78 patients with liver cirrhosis by ELISA. Results. The significant increase of plasma VEGF and sVEGF-R1 was observed in liver cirrhosis compared to healthy individuals (153.1+/-51.9 vs. 46.8+/-4.1pg/mL, P<0.05; 279.8+/-34.3 vs. 105.1+/-5.9pg/mL, P<0.001, respectively). Plasma VEGF and foremost sVEGF R1 showed significant associations with biochemical indices of liver function. Among clinical parameters, only ascites revealed significant association with plasma VEGR and sVEGF-R1. VEGF and sVEGF-R1 were increasedrespectively to the degree of liver insufficiency. It was demonstrated through a significant positive correlation with Child-Pugh score and MELD classification. In conclusion, our study suggests that serum VEGF and VEGF-R1 may reflect the hepatic function impairment in liver cirrhosis and seems to be associated with portal hypertension symptoms.
机译:最近的研究提供了体内证据,证明在门脉高压和肝硬化的动物模型中血管生成增加,这与血管内皮生长因子的表达增加有关。该研究的目的是评估肝硬化患者血浆VEGF及其受体的血浆浓度,以及可能与肝功能不全程度的关系。方法。 ELISA法测定了78例肝硬化患者血浆中的血管内皮生长因子(VEGF)及其可溶性受体sVEGF-R1,sVEGF-R2。结果。与健康个体相比,肝硬化患者血浆VEGF和sVEGF-R1显着增加(153.1 +/- 51.9 vs.46.8 +/- 4.1pg / mL,P <0.05; 279.8 +/- 34.3 vs.105.1 + / -5.9pg / mL,分别P <0.001)。血浆VEGF和最重要的sVEGF R1与肝功能的生化指标显着相关。在临床参数中,仅腹水显示与血浆VEGR和sVEGF-R1显着相关。 VEGF和sVEGF-R1分别增加至肝功能不全的程度。与Child-Pugh评分和MELD分类呈显着正相关,证明了这一点。总之,我们的研究表明,血清VEGF和VEGF-R1可能反映了肝硬化肝功能损害,并且似乎与门脉高压症状有关。

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