...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cytokine >IGF-II and IL-2 act synergistically to alter HDAC1 expression following treatments with trichostatin a.
【24h】

IGF-II and IL-2 act synergistically to alter HDAC1 expression following treatments with trichostatin a.

机译：在用曲古抑菌素a处理后，IGF-II和IL-2协同作用来改变HDAC1的表达。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Histone deacetylases play key roles in the regulation of gene transcription. Studies have shown that expression of interleukins IL-2 and IL-8, and insulin-like growth factor 2 (IGF2) are affected by treatment with histone deacetylase inhibitors. We have previously shown that the gene for histone deacetylase 1 (HDAC1) is upregulated following treatment with TSA. The murine homologue of this gene has been reported to be inducible by IL-2. In this study, we have examined the effects IL-2, IGF-II and TSA have on HDAC1 expression in the human hepatocellular carcinoma derived cell line Hep3B. Our results indicate that in contrast to the mouse, HDAC1 is not inducible by IL-2. However, in TSA treated cells, IL-2 and IGF-II were found to act synergistically to reduce TSA induced HDAC1 mRNA levels almost to normal. Copyright 2000 Academic Press.
机译：组蛋白脱乙酰基酶在调节基因转录中起关键作用。研究表明，用组蛋白脱乙酰基酶抑制剂治疗可影响白介素IL-2和IL-8以及胰岛素样生长因子2（IGF2）的表达。先前我们已经证明，用TSA处理后，组蛋白脱乙酰基酶1（HDAC1）的基因被上调。据报道该基因的鼠同源物可被IL-2诱导。在这项研究中，我们检查了IL-2，IGF-II和TSA对人肝癌衍生的细胞系Hep3B中HDAC1表达的影响。我们的结果表明，与小鼠相反，IL-2不能诱导HDAC1。然而，在经TSA处理的细胞中，发现IL-2和IGF-II具有协同作用，可将TSA诱导的HDAC1 mRNA水平降低至几乎正常水平。版权所有2000学术出版社。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号