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MCP-1 and MIP-1alpha expression in a model resembling early immune response to dengue.

机译：MCP-1和MIP-1alpha在模型中的表达类似于对登革热的早期免疫反应。

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摘要

Dengue virus has become endemic in most tropical urban areas throughout the world, and DHF has appeared concomitantly with this expansion. The intensity of dengue virus replication during the early stages of infection could determine clinical outcomes; therefore, it is important to understand the impact of dengue virus infection on the earliest immune defense against microbial infection, which also strongly regulates the adaptive immune responses. This study was aimed at evaluating the expression of the CC-chemokines MIP-1alpha/CCL3 and MCP-1/CCL2 in peripheral blood leukocytes using an ex vivo model resembling dengue infection in vivo, in subjects with a well characterized dengue immune background, due to the exceptional Cuban epidemiological situation in dengue. The expression of IFNgamma, TNFalpha and IL10 was also evaluated, giving insight about the role of MCP-1 and MIP-1alpha in the interplay between innate and adaptive immunity. From individuals with different dengue immune background after dengue virus challenge, increased and different expression of the chemokines and cytokines studied was verified in peripheral blood mononuclear cells, thus demonstrating that the previous immunity to a dengue virus serotype has a strong influence on the early immune response after dengue re-infection.
机译：登革热病毒已成为世界上大多数热带城市地区的地方性疾病，随着这种扩散，DHF也随之出现。感染初期登革热病毒复制的强度可以决定临床结局。因此，重要的是要了解登革热病毒感染对最早抵抗微生物感染的免疫防御的影响，这也强烈调节了适应性免疫反应。这项研究的目的是在具有特征明确的登革热免疫背景的受试者中，使用类似于体内登革热感染的离体模型评估外周血白细胞中CC趋化因子MIP-1alpha / CCL3和MCP-1 / CCL2的表达。古巴登革热流行病的特殊情况。还评估了IFNgamma，TNFα和IL10的表达，从而深入了解MCP-1和MIP-1alpha在先天免疫与适应性免疫之间的相互作用中的作用。从感染登革热病毒后具有不同登革热免疫背景的个体中，证实了外周血单个核细胞中趋化因子和细胞因子表达的增加和不同表达，从而证明先前对登革热病毒血清型的免疫力对早期免疫反应具有重要影响登革热再感染后。

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