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首页> 外文期刊>Cytokine >Effect of psoriasis activity on VEGF and its soluble receptors concentrations in serum and plaque scales.
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Effect of psoriasis activity on VEGF and its soluble receptors concentrations in serum and plaque scales.

机译:银屑病活性对血清和斑块中VEGF及其可溶性受体浓度的影响。

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摘要

Vascular endothelial growth factor (VEGF) demonstrating pro-angiogenic activity promote new blood vessel formation in psoriatic lesions. The aim of this study was to evaluate the serum concentrations of VEGF, its soluble receptors (sVEGF R1 and R2) and VEGF content in scales of patients with psoriasis. To analyze possible association with activity of the disease, serum and scales from plaques were collected from 59 patients with exacerbated chronic plaque-type psoriasis. Mean concentrations of VEGF and sVEGF R1 in sera of patients were respectively two and four times higher than in healthy controls. Serum VEGF and sVEGF R1, but not sVEGF R2 demonstrated significant correlation with psoriasis area and severity index (PASI). There was also significant correlation between VEGF levels in serum and scales. Serum sVEGF R1 concentration was significantly elevated even in patients with low psoriasis activity (PASI<10), whereas increase of serum VEGF became significant in patients with medium activity (PASI: 10-20). Levels of serum VEGF and sVEGF R1 were the highest in patients with PASI>20. We confirmed association of both serum and scales VEGF concentrations with degree of psoriasis activity and demonstrated predominant increase of sVEGF R1 vs. VEGF in serum of patients with low psoriasis activity.
机译:证明促血管生成活性的血管内皮生长因子(VEGF)促进银屑病病变中新血管的形成。这项研究的目的是评估牛皮癣患者的血清中VEGF的浓度,其可溶性受体(sVEGF R1和R2)以及VEGF的含量。为了分析与疾病活动性的可能关联,从59例慢性斑块型牛皮癣加重患者中收集了血清和斑块。患者血清中VEGF和sVEGF R1的平均浓度分别比健康对照组高2倍和4倍。血清VEGF和sVEGF R1而非sVEGF R2表现出与牛皮癣面积和严重程度指数(PASI)显着相关。血清中VEGF水平与鳞片之间也存在显着相关性。即使在银屑病活性低的患者(PASI <10)中,血清sVEGF R1的浓度也显着升高,而在中等活性的患者中,血清VEGF的升高也显着(PASI:10-20)。 PASI> 20的患者血清VEGF和sVEGF R1水平最高。我们证实了血清和鳞状VEGF浓度均与牛皮癣活动程度相关,并证明了牛皮癣活动低的患者血清中sVEGF R1与VEGF的显着增加。

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