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首页> 外文期刊>Cytokine >IL-6, but not TNF-alpha, increases plasma YKL-40 in human subjects.
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IL-6, but not TNF-alpha, increases plasma YKL-40 in human subjects.

机译：IL-6，而不是TNF-α，可增加人类受试者的血浆YKL-40。

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摘要

Plasma levels of YKL-40 are elevated in patients with systemic infection, inflammatory disorders and cancer. Both monocytes/macrophages, neutrophils, and cancer cells have the capacity to produce YKL-40, but the regulation during the inflammatory response is unknown. To study the possible role of interleukin-6 (IL-6) and tumor necrosis factor (TNF)-alpha in the regulation of YKL-40 plasma levels, we included healthy men, who received either recombinant human (rh)IL-6 (n=6), rhTNF-alpha (n=8) or vehicle (n=7) for 3h. The plasma levels of IL-6 and TNF-alpha reached approximately 150 and approximately 18 pg/ml, respectively, during the infusions. Following the IL-6 infusion, the plasma level of YKL-40 increased from approximately 30 to approximately 57 ng/ml (p<0.05) at 24h, and returned to normal values after 48 h. The plasma level of YKL-40 did not change during TNF-alpha infusion or infusion of vehicle. These data demonstrate that IL-6, but not TNF-alpha, has a key-role in the regulation of plasma YKL-40 levels during inflammation.
机译：患有全身感染，炎性疾病和癌症的患者的YKL-40血浆水平升高。单核细胞/巨噬细胞，嗜中性粒细胞和癌细胞均具有产生YKL-40的能力，但在炎症反应过程中的调节尚不清楚。为了研究白介素6（IL-6）和肿瘤坏死因子（TNF）-α在YKL-40血浆水平调节中的可能作用，我们纳入了接受重组人（rh）IL-6（ n = 6），rhTNF-alpha（n = 8）或媒介物（n = 7）持续3h。在输注过程中，IL-6和TNF-α的血浆水平分别达到约150 pg / ml和约18 pg / ml。输注IL-6后，YKL-40的血浆水平在24小时从约30 ng / ml增加到约57 ng / ml（p <0.05），并在48 h后恢复到正常值。在TNF-α输注或赋形剂输注过程中，YKL-40的血浆水平没有变化。这些数据表明，在炎症过程中，IL-6（而非TNF-α）在调节血浆YKL-40水平方面具有关键作用。

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