• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Brain topography >Neural Mechanism Underling Comprehension of Narrative Speech and Its Heritability: Study in a Large Population
【24h】

Neural Mechanism Underling Comprehension of Narrative Speech and Its Heritability: Study in a Large Population

机译：叙事言论的神经机制及其遗传性：大人物研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Comprehension of narratives constitutes a fundamental part of our everyday life experience. Although the neural mechanism of auditory narrative comprehension has been investigated in some studies, the neural correlates underlying this mechanism and its heritability remain poorly understood. We investigated comprehension of naturalistic speech in a large, healthy adult population (n = 429; 176/253 M/F; 22-36 years of age) consisting of 192 twin pairs (49 monozygotic and 47 dizygotic pairs) and 237 of their siblings. We used high quality functional MRI datasets from the Human Connectome Project (HCP) in which a story-based paradigm was utilized for the auditory narrative comprehension. Our results revealed that narrative comprehension was associated with activations of the classical language regions including superior temporal gyrus (STG), middle temporal gyrus (MTG), and inferior frontal gyrus (IFG) in both hemispheres, though STG and MTG were activated symmetrically and activation in IFG were left-lateralized. Our results further showed that the narrative comprehension was associated with activations in areas beyond the classical language regions, e.g. medial superior frontal gyrus (SFGmed), middle frontal gyrus (MFG), and supplementary motor area (SMA). Of subcortical structures, only the hippocampus was involved. The results of heritability analysis revealed that the oral reading recognition and picture vocabulary comprehension were significantly heritable (h (2) > 0.56, p < 10(- 13)). In addition, the extent of activation of five areas in the left hemisphere, i.e. STG, IFG pars opercularis, SFGmed, SMA, and precuneus, and one area in the right hemisphere, i.e. MFG, were significantly heritable (h (2) > 0.33, p < 0.0004). The current study, to the best of our knowledge, is the first to investigate auditory narrative comprehension and its heritability in a large healthy population. Referring to the excellent quality of the HCP data, our results can clarify the functional contributions of linguistic and extra-linguistic cortices during narrative comprehension.
机译：对叙述的理解构成了我们日常生活经验的基本部分。虽然在某些研究中已经调查了听觉叙事理解的神经机制，但这种机制的神经相关性和其遗传性仍然明白很差。我们调查了对大量健康成年人群的自然讲话的理解（n = 429; 176/253 m / f; 22-36岁）由192人（49个单脆性和47个Dizygotic对）和237对的兄弟姐妹组成。我们使用了来自人类连接项目（HCP）的高质量功能MRI数据集，其中利用了基于故事的范例进行了听觉叙事理解。我们的研究结果表明，叙事理解与在两个半球中的古代颞型（STG），中间时颞子（STG），中间颞子（MTG）和下额相（IFG）的激活相关，尽管STG和MTG对称和活化在IFG中被留下来。我们的结果进一步表明，叙事理解与超出古典语言地区的地区的激活有关，例如，内侧高级额相回归（SFGMED），中正面回到（MFG）和补充电机区域（SMA）。涉及过型海马的结构。遗传性分析结果显示，口腔读数识别和图片词汇理解是显着的遗传性（H（2）> 0.56，P <10（ - 13））。此外，左半球中的五个区域的激活程度，即STG，IFG分析术，SFGMED，SMA和PREANEUS，以及右半球中的一个区域，即MFG，具有显着遗传的（H（2）> 0.33 ，p <0.0004）。据我们所知，目前的研究是第一个调查听觉叙事理解和其在大量健康人口中的可遗产。参考HCP数据的卓越品质，我们的结果可以在叙事理解过程中阐明语言和语言皮质的功能贡献。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号