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首页> 外文期刊>Brain injury: BI >Pilot investigation of a novel white matter imaging technique in Veterans with and without history of mild traumatic brain injury
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Pilot investigation of a novel white matter imaging technique in Veterans with and without history of mild traumatic brain injury

机译：具有轻度创伤性脑损伤的退伍军人新型白质成像技术的试验研究

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Objective: The objective of this study is to assess utility of in vivo myelin imaging in combat Veterans with and without history of mild traumatic brain injury (mTBI). We hypothesized that those with history of mTBI would have lower myelin water fraction (MWF), a marker of myelin integrity and content, than those without, and lower MWF would be associated with worse speeded attention/processing speed.Research design: Combat Veterans (N?=?70) with (n?=?42) and without history of mTBI (n?=?28) underwent neuroimaging including a novel myelin-sensitive magnetic resonance imaging technique (multicomponent-driven equilibrium single-pulse observation of T1/T2; mcDESPOT) and comprehensive neuropsychological assessment.Results: There were no group differences in MWF using a region-of-interest approach. An exploratory analysis applying limited spatial constraints, however, revealed significantly more ‘potholes’ (clusters of low MWF) in Veterans with history of mTBI compared to those without. Lower MWF across several ROIs was associated with worse performance on a speeded attention task across groups.Conclusion: Veterans in the post-acute period following mTBI showed limited and spatially heterogeneous MWF changes and myelin integrity was significantly related to processing speed. This preliminary evidence for usefulness of mcDESPOT in combat Veterans with history of mTBI warrants future research to determine mcDESPOT’s relative utility compared to techniques such as diffusion tensor imaging.
机译：目的：本研究的目的是评估在战斗退伍军人的体内髓鞘成像的实用性，没有轻度创伤性脑损伤（MTBI）。我们假设有MTBI历史的人将具有较低的髓鞘水分（MWF），髓鞘的标记，而不是没有没有的内容，下部MWF会与更差的超速关注/加工速度相关联。研究设计：战斗退伍军人（ n？=Δ70）与（n？=Δ22）且没有MTBI的历史（n？=Δ28）接受神经影像体，包括新的髓鞘敏感磁共振成像技术（多组分驱动的平衡单脉冲观察T1 / T2; MCDESPOT）和综合神经心理学评估。结果：MWF使用令人兴趣区域的方法没有组差异。然而，应用有限的空间限制的探索性分析在退伍军人中揭示了更多的“低MWF集群”，与那些没有MTBI的历史。跨越几个ROI的较低的MWF与跨组的超速关注任务的性能更糟糕。结论：MTBI后急性期间的退伍军人显示有限，空间异质的MWF变化，髓鞘完整性与加工速度显着相关。对于MTBI历史的战斗资深人士与MTBI历史上的MCDESPOT有用性的初步证据需要未来的研究，以确定与扩散张量成像等技术相比的MCDESPOT的相对效用。

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