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首页> 外文期刊>Brain imaging and behavior >White matter abnormalities in mild traumatic brain injury with and without post-traumatic stress disorder: a subject-specific diffusion tensor imaging study
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White matter abnormalities in mild traumatic brain injury with and without post-traumatic stress disorder: a subject-specific diffusion tensor imaging study

机译：白质异常在轻度创伤性脑损伤中，没有创伤后应激障碍：特定于课程的扩散张量成像研究

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Mild traumatic brain injuries (mTBIs) are often associated with posttraumatic stress disorder (PTSD). In cases of chronic mTBI, accurate diagnosis can be challenging due to the overlapping symptoms this condition shares with PTSD. Furthermore, mTBIs are heterogeneous and not easily observed using conventional neuroimaging tools, despite the fact that diffuse axonal injuries are the most common injury. Diffusion tensor imaging (DTI) is sensitive to diffuse axonal injuries and is thus more likely to detect mTBIs, especially when analyses account for the inter-individual variability of these injuries. Using a subject-specific approach, we compared fractional anisotropy (FA) abnormalities between groups with a history of mTBI (n = 35), comorbid mTBI and PTSD (mTBI + PTSD; n = 22), and healthy controls (n = 37). We compared all three groups on the number of abnormal FA clusters derived from subject-specific injury profiles (i.e., individual z-score maps) along a common white matter skeleton. The mTBI + PTSD group evinced a greater number of abnormally low FA clusters relative to both the healthy controls and the mTBI group without PTSD (p .05). Across the groups with a history of mTBI, increased numbers of abnormally low FA clusters were significantly associated with PTSD symptom severity, depression, post-concussion symptoms, and reduced information processing speed (p .05). These findings highlight the utility of subject-specific microstructural analyses when searching for mTBI-related brain abnormalities, particularly in patients with PTSD. This study also suggests that patients with a history of mTBI and comorbid PTSD, relative to those without PTSD, are at increased risk of FA abnormalities.
机译：轻度创伤性脑损伤（MTBIS）通常与错误后应激障碍（PTSD）有关。在慢性MTBI的情况下，由于与PTSD的重叠症状，准确的诊断可能是具有挑战性的。此外，尽管弥漫性轴突损伤是最常见的损伤，但MTBIS是异构的并且不容易观察使用传统的神经影像工具。扩散张量成像（DTI）对弥漫性轴突损伤敏感，因此更有可能检测MTBIS，特别是当分析算用于这些伤害的间间可变性时。使用特异性方法，我们将分数各向异性（FA）与MTBI（n = 35），COMBID MTBI和PTSD（MTBI + PTSD; N = 22）的历史进行比较（N = 35）之间的分数各向异性（FA）异常，以及健康对照（n = 37） 。我们将所有三组与沿共同的白物骨架源自常见的伤害概况（即个体Z分数图）的异常FA簇数。 MTBI + PTSD组相对于健康对照和没有PTSD的MTBI组，更大数量的异常低的FA簇（P <.05）。在具有MTBI的历史的组中，增加的异常低的FA簇数量显着与PTSD症状严重程度，抑郁症，震荡症状和减少信息处理速度有显着相关（P <.05）。这些发现在寻找MTBI相关的脑异常时突出了主题微观结构分析的效用，特别是在应激障碍患者中。本研究还表明，患有MTBI和可嗜血症的患者的患者，相对于没有PTSD的那些，具有增加的FA异常的风险。

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