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首页> 外文期刊>Cytokine >Serum resistin in older patients with hip fracture: Relationship with comorbidity and biochemical determinants of bone metabolism.
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Serum resistin in older patients with hip fracture: Relationship with comorbidity and biochemical determinants of bone metabolism.

机译：老年髋部骨折患者的血清抵抗素：与合并症和骨代谢生化决定因素的关系。

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OBJECTIVES: To determine the relationship of serum resistin concentrations to biochemical determinants of bone metabolism, comorbidity and outcomes in patients with hip fracture (HF). METHODS: In 256 consecutive patients (mean age 81.9+/-7.8 years; 71.1% women) serum levels of resistin (determined by ELISA), biochemical parameters of bone turnover and mineral metabolism as well as routine haematological and biochemical parameters were measured. Clinical data were recorded prospectively. RESULTS: In multivariate analysis cervical HF (OR=1.81; 95% CI 1.05-3.11), diabetes (OR=2.60; 95% CI 1.23-5.51) and history of stroke (OR=2.67; 95% CI 1.17-6.13) were significant independent predictors of higher resistin levels (>/=16.26 ng/ml, median value). The independent correlates of serum resistin levels in patients with cervical HF were serum osteocalcin and magnesium (both negatively associated) and in patients with trochanteric HF, serum PTH, calcium and age (all positively associated). Resistin and glomerular filtration rate were the only independent (inverse) predictors of serum osteocalcin. Resistin levels on admission did not predict short-term outcomes. CONCLUSIONS: In older patients with HF there is a significant association of higher resistin levels with cervical fracture, type 2 diabetes and history of stroke, which is partly influenced by the reciprocal interaction between resistin and osteocalcin. However, the design of the study does not prove causality and further prospective studies are needed to clarify these relationships.
机译：目的：确定血清抵抗素浓度与髋部骨折（HF）患者骨代谢，合并症和预后的生化决定因素之间的关系。方法：连续256名患者（平均年龄81.9 +/- 7.8岁;女性占71.1％）的血清抵抗素水平（通过ELISA测定），骨转换和矿物质代谢的生化参数以及常规的血液学和生化参数被测量。前瞻性记录临床数据。结果：在多变量分析中，宫颈HF（OR = 1.81; 95％CI 1.05-3.11），糖尿病（OR = 2.60; 95％CI 1.23-5.51）和中风病史（OR = 2.67; 95％CI 1.17-6.13）为较高的抵抗素水平（> / = 16.26 ng / ml，中值）的重要独立预测因子。子宫颈HF患者血清抵抗素水平的独立相关因素是血清骨钙素和镁（两者呈负相关），与股骨转子性HF患者血清PTH，钙和年龄（均呈正相关）。抵抗素和肾小球滤过率是血清骨钙素的唯一独立（逆向）预测因子。入院时的抵抗素水平不能预测短期结果。结论：在老年HF患者中，较高的抵抗素水平与宫颈骨折，2型糖尿病和中风史密切相关，这在一定程度上受抵抗素和骨钙素之间的相互作用的影响。但是，研究的设计并没有证明因果关系，需要进一步的前瞻性研究来阐明这些关系。

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