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首页> 外文期刊>Cytokine >GSTM1 null allele is a risk factor for gastric cancer development in Asians.
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GSTM1 null allele is a risk factor for gastric cancer development in Asians.

机译：GSTM1无效等位基因是亚洲人胃癌发展的危险因素。

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Glutathione S-transferase M1 (GSTM1), which plays an important role in detoxification pathways to protect against damage caused by reactive metabolites of chemicals, has been considered as potential gastric cancer susceptibility genes. However, the published data on the association between GSTM1 presentull polymorphism and gastric cancer risk are still inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. Totally, 44 studies including 5440 cases and 11607 controls were involved in the analysis. When all studies were pooled into the meta-analysis, obviously increased gastric cancer risk was found in null genotype carriers (OR=1.19, 95% CI: 1.08-1.33). When stratified by ethnicity, obviously evaluated risk was found in Asians (OR=1.31, 95% CI: 1.11-1.54) but not reached to statistically significance in Caucasians (OR=1.11, 95% CI: 0.96-1.28). In the subgroup analysis by hospital-based studies or population-based studies, statistically significantly elevated risk was found in hospital-based studies (OR=1.34, 95% CI: 1.07-1.67) but not reached to statistically significance in population-based studies (OR=1.11, 95% CI: 0.99-1.25). In summary, this meta-analysis result indicates that the GSTM1 null genotype is a low-penetrant risk factor for gastric cancer development in Asians.
机译：谷胱甘肽S-转移酶M1（GSTM1）在排毒途径中起着重要作用，以防止化学物质的反应性代谢产物引起的损害，被认为是潜在的胃癌易感基因。但是，有关GSTM1存在/无效多态性与胃癌风险之间关系的已发表数据尚无定论。为了获得更精确的关系估计，进行了荟萃分析。分析共涉及44项研究，包括5440例病例和11607例对照。当所有研究汇总到荟萃分析中时，在无效基因型携带者中发现胃癌风险明显增加（OR = 1.19，95％CI：1.08-1.33）。当按种族进行分层时，在亚洲人中发现了明显评估的风险（OR = 1.31，95％CI：1.11-1.54），但在白种人中却没有达到统计学意义（OR = 1.11，95％CI：0.96-1.28）。在基于医院的研究或基于人群的研究的亚组分析中，在基于医院的研究中发现统计学上显着升高的风险（OR = 1.34，95％CI：1.07-1.67），但在基于人群的研究中未达到统计学意义（OR = 1.11，95％CI：0.99-1.25）。总之，这项荟萃分析结果表明，GSTM1无效基因型是亚洲人胃癌发展的低渗透危险因素。

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