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TNF-alpha system and lung function impairment in obesity.

机译：肥胖中的TNF-α系统和肺功能受损。

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A potential interaction between pulmonary function, abnormal adipose tissue activity, and systemic inflammation has been suggested. This study explores the relationship between circulating soluble TNF-alpha receptors (sTNF-R1 and sTNF-R2) and respiratory function parameters in obese subjects. Thirty-one non-diabetic morbidly obese women with a history of non-smoking and without prior cardiovascular or respiratory disease were prospectively recruited in the outpatient Obesity Unit of a referral center. Pulmonary function test included a forced spirometry, static pulmonary volume measurements, non-attended respiratory polygraphy, and arterial gas blood sampling. Circulating levels of sTNFR-R1, sTNF-R2, interleukine 6 and adiponectin were determined using ELISA. Statistical analysis included a multivariate regression analysis taking into account the potential confounders. sTNF-R1 positively correlated with BMI (r=0.571, p=0.001) and arterial carbon dioxide pressure (PaCO(2), r=0.381, p=0.038), but negatively with forced expiratory volume in 1s (FEV(1), r=-0.437, p=0.012), maximum midexpiratory flow (FEF(25-75), r=-0.370, p=0.040) and forced vital capacity (FVC, r=-0.483, p=0.005). However, no correlation between sTNF-R2 and BMI and either pulmonary function tests or arterial blood samples was observed. Multiple linear regression analysis showed that sTNF-R1 independently predicted FEV(1) (beta=-0.437, p=0.012) and FVC (beta=-0.483, p=0.005). Thus, circulating levels of sTNF-R1, but not sTNF-R2, are related to reduced lung volumes and airflow limitation in morbidly obese patients prior to the development of a clinically recognized respiratory disease. Therefore, studies addressed to evaluating the potential beneficial effect of anti-TNF-alpha agents on pulmonary function tests in obese subjects seem warranted.
机译：已经提出了肺功能，异常脂肪组织活性和全身性炎症之间的潜在相互作用。这项研究探讨了肥胖受试者中循环可溶性TNF-α受体（sTNF-R1和sTNF-R2）与呼吸功能参数之间的关系。前瞻性地在转诊中心门诊肥胖病科招募了31名具有非吸烟史且无心血管疾病或呼吸系统疾病的非糖尿病病态肥胖妇女。肺功能测试包括强制肺活量测定，静态肺体积测量，无人值守呼吸描记法和动脉血气采样。使用ELISA确定sTNFR-R1，sTNF-R2，白细胞介素6和脂联素的循环水平。统计分析包括考虑了潜在混杂因素的多元回归分析。 sTNF-R1与BMI（r = 0.571，p = 0.001）和动脉二氧化碳压（PaCO（2），r = 0.381，p = 0.038）呈正相关，但与1s的呼气量呈负相关（FEV（1）， r = -0.437，p = 0.012），最大呼气中期流量（FEF（25-75），r = -0.370，p = 0.040）和强制肺活量（FVC，r = -0.483，p = 0.005）。但是，未观察到sTNF-R2和BMI与肺功能检查或动脉血样本之间的相关性。多元线性回归分析显示sTNF-R1独立预测FEV（1）（beta = -0.437，p = 0.012）和FVC（beta = -0.483，p = 0.005）。因此，在临床公认的呼吸系统疾病发展之前，病态肥胖患者的sTNF-R1而不是sTNF-R2的循环水平与肺容量减少和气流受限有关。因此，似乎有必要进行评估抗TNF-α药物对肥胖受试者肺功能测试的潜在有益作用的研究。

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