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首页> 外文期刊>Cytokine >Sublingual mucosa: A new vaccination route for systemic and mucosal immunity.
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Sublingual mucosa: A new vaccination route for systemic and mucosal immunity.

机译：舌下粘膜：一种新的全身和粘膜免疫接种途径。

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Needle-free vaccine delivery has become a global priority, both to eliminate the risk of improper and unsafe needle use and to simplify vaccination procedures. In pursuit of greater ease of vaccination, a number of needle-free delivery routes have been explored, with mucosal routes being perhaps the most prominent. Since the vaccine administration route significantly affects immune responses, numerous researchers are attempting to develop alternative vaccine delivery methods including a mucosal route. My group's recent studies demonstrate the potential of the sublingual (s.l.) route for delivering vaccines capable of inducing mucosal as well as systemic immune responses. Sublingual administration conferred effective protection against a lethal challenge with influenza virus (H1N1) or genital papillomavirus. Moreover, CCR7-CCL19/CCL21-regulated dendritic cells are responsible for activation of T and B cells following s.l. administration. This review highlights current knowledge about the safety and effectiveness of s.l. vaccination and describes how s.l. vaccination can induce both systemic and mucosal immunity.
机译：无针疫苗交付已成为全球优先事项，既可以消除不正确和不安全使用针头的风险，又可以简化疫苗接种程序。为了更容易接种疫苗，已经探索了许多无针递送途径，其中粘膜途径可能是最突出的。由于疫苗的给药途径会显着影响免疫反应，因此许多研究人员正在尝试开发包括粘膜途径在内的替代疫苗输送方法。我小组最近的研究证明了舌下（s.l.）途径可能产生能够诱导粘膜和全身免疫反应的疫苗。舌下给药可有效预防流感病毒（H1N1）或生殖器乳头瘤病毒的致死性攻击。此外，CCR7-CCL19 / CCL21调节的树突状细胞负责s.l后T和B细胞的活化。行政。这篇评论重点介绍了有关s.l.的安全性和有效性的最新知识。接种疫苗，并描述s.l.疫苗接种可以诱导全身和粘膜免疫。

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