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首页> 外文期刊>Cytokine >Mouse T helper 17 phenotype: not so different than in man after all.
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Mouse T helper 17 phenotype: not so different than in man after all.

机译：小鼠T辅助细胞17表型：毕竟与人没有什么不同。

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摘要

CD4+ T-helper (TH) cells that selectively produce interleukin (IL)-17 (TH17) are thought to be critical for host defense and autoimmunity. Three major dogmas were established, based on initial studies performed in murine models, and initially extrapolated by many researchers to human pathophysiology. First, TH17 cells represent a fixed CD4+ T-cell effector phenotype without any developmental relationship with TH1 cells. Second, TH17 cells are exclusively responsible for pathogenicity in several chronic inflammatory disorders, TH1 cell being instead protective. Finally, TH17 cells originate from naive TH cells in response to the combined activity of transforming growth factor (TGF)-beta and IL-6, whereas in the presence of TGF-beta alone the same cells develop into Foxp3+ T regulatory cells. Studies performed in human demonstrated apparent species-specific differences, such as the expression by TH17 cells of the TH1-related transcription factor T-bet, the IL-12-inducible plasticity of TH17 cells into TH1 cells, and the dispensability of TGF-beta signaling for their development. As discussed in this short review, recent studies in mice have led to reassessment of the three above-mentioned dogmas regarding the TH17 phenotype, suggesting that studies in humans actually better depicted TH17 cells than initial studies in mice did.
机译：选择性产生白介素（IL）-17（TH17）的CD4 + T辅助（TH）细胞被认为对宿主防御和自身免疫至关重要。基于在鼠模型中进行的初步研究，建立了三个主要教条，并最初被许多研究人员推断为人类病理生理学。首先，TH17细胞代表固定的CD4 + T细胞效应表型，与TH1细胞无任何发育关系。其次，TH17细胞专门负责几种慢性炎症性疾病的致病性，而TH1细胞则具有保护作用。最后，TH17细胞起源于幼稚的TH细胞，以响应转化生长因子（TGF）-β和IL-6的联合活性，而在存在TGF-β的情况下，相同的细胞会发育为Foxp3 + T调节细胞。在人类中进行的研究表明，明显的物种特异性差异，例如TH17细胞表达TH1相关转录因子T-bet，IL-12诱导的TH17细胞可塑性转化为TH1细胞以及TGF-beta的可分配性表示他们的发展。正如这篇简短评论所讨论的那样，最近在小鼠中的研究导致对上述三个关于TH17表型的教条的重新评估，这表明与小鼠的初始研究相比，人体研究实际上更好地描绘了TH17细胞。

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