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首页> 外文期刊>Cytokine >Cytokine gene polymorphisms are associated with markers of disease severity and prognosis in patients with idiopathic dilated cardiomyopathy.
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Cytokine gene polymorphisms are associated with markers of disease severity and prognosis in patients with idiopathic dilated cardiomyopathy.

机译：细胞因子基因多态性与特发性扩张型心肌病患者的疾病严重程度和预后相关。

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摘要

AIMS: To identify potential genetic associations of five cytokine gene polymorphisms with disease severity and prognosis in patients with idiopathic dilated cardiomyopathy (DCM). METHODS AND RESULTS: Eighty patients with DCM were genotyped for transforming growth factor beta1 (TGF-beta1)+869 T/C (codon10 Leu-->Pro), TGF-beta1 +915 G/C (codon25 Arg-->Pro), interleukin (IL)-6 -174G/C, tumor necrosis factor-alpha (TNF-alpha) -308A/G, interferon-gamma (IFN-gamma) +874T/A, IL-10 -1082A/G, IL-10 -819T/C and IL-10 -592A/C gene polymorphisms. In homozygous TT patients for TGF-beta1 +869 T/C polymorphism mean VO(2) max was significantly higher than in CC homozygous patients (25.67+/-6.73ml/kg/min vs. 20.29+/-6.35 ml/kg/min, p = 0.046), which remained significant only for patients younger than 39 years old after adjusting for age and sex (p = 0.009). C carriers of TGF-beta1 +915 G/C polymorphism are 4.2 times more likely to be in a worse NYHA stage (III-IV) than non C carriers [OR: 4.25, 95% CI (1.53-11.80), p = 0.006]. Patients GG homozygous for IL-6 -174G/C polymorphism presented greater left ventricle end-systolic (p = 0.018) and end-diastolic (p = 0.04) diameters in comparison to the CC homozygous. The AA homozygote for IFN-gamma +874T/A polymorphism (p = 0.02) and the combination of the TGF-beta1 +869 T/C and TGF-beta1 +915 G/C genotypes were associated with adverse outcome (p = 0.014). CONCLUSION: Specific cytokine gene polymorphisms seem to be associated with worse prognosis as well as with measures of disease severity in DCM.
机译：目的：确定特发性扩张型心肌病（DCM）患者中五种细胞因子基因多态性与疾病严重程度和预后的潜在遗传关联。方法和结果：对80例DCM患者进行了基因型分型，分别为转化生长因子beta1（TGF-beta1）+869 T / C（密码子10 Leu-> Pro），TGF-beta1 +915 G / C（密码子25 Arg-> Pro）。 ，白介素（IL）-6 -174G / C，肿瘤坏死因子-α（TNF-alpha）-308A / G，干扰素-γ（IFN-γ）+ 874T / A，IL-10 -1082A / G，IL- 10 -819T / C和IL-10 -592A / C基因多态性。纯合TT患者的TGF-beta1 +869 T / C多态性平均VO（2）max显着高于CC纯合患者（25.67 +/- 6.73ml / kg / min与20.29 +/- 6.35 ml / kg / min，p = 0.046），仅在调整了年龄和性别后才对39岁以下的患者有意义（p = 0.009）。与非C携带者相比，TGF-beta1 +915 G / C多态性的C携带者处于较差的NYHA阶段（III-IV）的可能性高4.2倍[OR：4.25，95％CI（1.53-11.80），p = 0.006 ]。与CC纯合子相比，IL-6 -174G / C多态性纯合的GG患者表现出更大的左心室收缩末期（p = 0.018）和舒张末期（p = 0.04）直径。 IFN-γ+ 874T / A多态性的AA纯合子（p = 0.02）和TGF-beta1 +869 T / C和TGF-beta1 +915 G / C基因型的组合与不良预后相关（p = 0.014） 。结论：特定的细胞因子基因多态性似乎与DCM的不良预后以及疾病严重程度的测定有关。

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