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首页> 外文期刊>Cytokine >Relationship of plasma leptin and adiponectin concentrations with menopausal status in Tunisian women.
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Relationship of plasma leptin and adiponectin concentrations with menopausal status in Tunisian women.

机译：突尼斯妇女血浆瘦素和脂联素浓度与绝经状态的关系。

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To evaluate the effect of menopausal status and body mass index (BMI) on circulating leptin and adiponectin concentrations and investigate whether there is an influence of menopausal transition on the relationships of these adipokines and leptin to adiponectin (L/A) ratio with lipid profile and insulin resistance in a sample of Tunisian women. One hundred ninety-six premenopausal (mean age 35.3+/-7.6 years) and 180 postmenopausal women (mean age 53.4+/-6.2 years) were included in the study. Participants were stratified into obese and normal weight groups based upon their baseline BMI. Fasting glucose, HDL-cholesterol (HDL-C), triglycerides (TG), total cholesterol (TC), insulin, leptin, and adiponectin concentrations were measured. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. Premenopausal women had significantly higher leptin and L/A ratio and lower adiponectin levels than postmenopausal women. Menopause had no effect on the mean values of BMI, insulin or HOMA-IR, HDL-C, and TG. Using a multiple linear regression model, menopausal status was identified, as significant independent predictor for leptin and adiponectin levels. Irrespective of the menopausal status, obese women exhibited higher leptin and L/A ratio and lower adiponectin levels compared to those with normal weight. Comparison between the two menopausal stages in obese and normal weight groups showed that leptin and L/A ratio decreased, while adiponectin increased from pre- to postmenopausal stage only in obese group. The L/A ratio correlated better with lipid profile and HOMA-IR in postmenopausal stage. The present study showed a significant interaction between menopause and BMI on leptin and adiponectin secretion. Menopausal transition affects the relationships of these adipokines with lipids and insulin resistance.
机译：评估更年期状态和体重指数（BMI）对循环中瘦素和脂联素浓度的影响，并探讨更年期过渡对这些脂肪因子和瘦素与脂联素（L / A）比率与血脂和血脂的关系的影响。突尼斯妇女样本中的胰岛素抵抗。该研究纳入了196名绝经前妇女（平均年龄35.3 +/- 7.6岁）和180名绝经后妇女（平均年龄53.4 +/- 6.2岁）。根据参与者的基线BMI将其分为肥胖和正常体重组。测量空腹血糖，HDL-胆固醇（HDL-C），甘油三酸酯（TG），总胆固醇（TC），胰岛素，瘦素和脂联素的浓度。计算胰岛素抵抗的稳态模型评估（HOMA-IR）。与绝经后妇女相比，绝经前妇女的瘦素和L / A比值显着升高，脂联素水平降低。更年期对BMI，胰岛素或HOMA-IR，HDL-C和TG的平均值没有影响。使用多元线性回归模型，确定更年期状态是瘦素和脂联素水平的重要独立预测因子。与绝经期相比，肥胖妇女的瘦素和L / A比值更高，脂联素水平也更低。肥胖组和正常体重组的两个更年期比较表明，仅肥胖组的瘦素和L / A比降低，而脂联素从绝经前到绝经后增加。绝经后L / A比值与血脂和HOMA-IR的相关性更好。本研究显示更年期与BMI在瘦素和脂联素分泌上有显着的相互作用。绝经期过渡会影响这些脂肪因子与脂质和胰岛素抵抗的关系。

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