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首页> 外文期刊>Breast cancer research and treatment. >Breast cancers in U.S. residing Indian-Pakistani versus non-Hispanic White women: comparative analysis of clinical-pathologic features, treatment, and survival.
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Breast cancers in U.S. residing Indian-Pakistani versus non-Hispanic White women: comparative analysis of clinical-pathologic features, treatment, and survival.

机译：美国母乳癌夺走印度巴基斯坦与非西班牙裔白人女性：对临床病理特征，治疗和生存的比较分析。

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South Asians from India and Pakistan represent one of the fastest growing immigrant populations in the US, yet there are limited data assessing breast cancers for this distinct ethnic sub-group. The aim of this study was to analyze clinical-pathologic, treatment and outcome characteristics of U.S.-residing Indian-Pakistani (IP) versus non-Hispanic white (NHW) female breast cancer patients to assess if any differences/disparities exist. The study cohort consisted of 2,393 IP and 555,832 NHW women (diagnosed 1988-2006) in the SEER database. Differences between the two populations were analyzed using chi-squared and multivariate regression analysis. Age-adjusted incidence, mortality, and relative survival rates were calculated for the two groups. Significant differences in the characteristics of the IP cohort's invasive disease included: younger median age at presentation; larger tumor size; higher stage, higher grade, more involved lymph-nodes, and more hormone receptor negative disease (all P < 0.01). The age-adjusted incidence and breast cancer mortality were lower in IP women. The relative survival at 5 years was statistically significant at 84% for IP versus 89% for NHW women, but was not significantly different on multivariate analysis (P > 0.05). Within each stage (Tis, I, II), there were no disparities in the rate of breast conservation surgery (BCS) or in the percentage of patients receiving adjuvant radiation after BCS for the 2 cohorts. Post-mastectomy radiation was delivered significantly more often in stage I/II IP patients undergoing mastectomy. In conclusion, this analysis suggests that while there appear to be significant differences in the features of breast cancers of US-residing IP women, no disparities were noted in the rates of breast conserving surgery or adjuvant radiation, as seen in some other ethnicities. The more aggressive clinical-pathologic features stage-for-stage in IP women may partially explain the more frequent use of post-mastectomy RT in this patient population. These findings warrant further investigation.
机译：来自印度和巴基斯坦的南亚斯代表了美国增长最快的移民群体之一，然而数据评估了这种独特的民族小组的乳腺癌。本研究的目的是分析美国的临床病理，治疗和结果特征，居住的印度巴基斯坦（IP）与非西班牙裔（NHW）女性乳腺癌患者，以评估是否存在任何差异/差异。研究队列由2,393名IP和555,832名NHW女性（1988-2006诊断为1988-2006）组成。使用CHI方向和多变量回归分析分析了两种群体之间的差异。为两组计算年龄调节的发病率，死亡率和相对存活率。 IP队列侵入性疾病特征的显着差异包括：呈现的年轻中位数;肿瘤大小较大;较高阶段，较高等级，更涉及的淋巴结，更高的激素受体阴性疾病（所有P <0.01）。 IP妇女的年龄调节发病率和乳腺癌死亡率降低。 5年的相对存活率为84％的IP对NHW女性的84％显着，但对多变量分析没有显着差异（P> 0.05）。在每个阶段（TIS，I，II）内，乳房保护手术（BCS）的速率没有差异，或者在BCS后接受辅助辐射的患者的百分比进行2个队列。在进行乳房切除术的I / II IP患者中，更常见的乳房切除术辐射更常见。总之，该分析表明，虽然美国居民妇女的乳腺癌的特征似乎存在显着差异，但在其他种族中所见，乳房保守手术或佐剂辐射的速率没有差异。 IP妇女阶段阶段阶段的临床病理特征较常见的临床病理学特征可能部分解释在该患者群体中更频繁地使用乳房切除术。这些调查结果需要进一步调查。

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