...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cytokine >Increased T regulatory cells and decreased Th1 pro-inflammatory cytokines correlate with culture-positive infection in febrile neutropenia childhood oncology patients.
【24h】

Increased T regulatory cells and decreased Th1 pro-inflammatory cytokines correlate with culture-positive infection in febrile neutropenia childhood oncology patients.

机译：T调节细胞增加和Th1促炎细胞因子减少与高热中性粒细胞减少症儿童肿瘤患者的培养阳性感染相关。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Paediatric oncology patients with febrile neutropenia are usually hospitalised and treated with empirical broad-spectrum antibiotic therapy to counter the risk of infection. However, there is currently no method available to rapidly identify bacteremia in these patients. T-helper-type-1 (Th1) cytokines are required for effective immune response to many pathogenic organisms and T regulatory cells are known suppressors of Th1 cells. We hypothesized that characterization of reduced intracellular Th1 cytokines and increased T regulatory cells (Tregs) may prove useful in identifying infection in childhood oncology patients with febrile neutropenia. METHODS: Intracellular Th 1 cytokines and Tregs were enumerated in peripheral blood from a group of childhood oncology patients with febrile neutropenia using multiparameter flow cytometry. RESULTS: There was a significant increase in the percentage of CD25(+) CD127(-) CD8(-) CD3(+) Tregs and a significant decrease in Th1 intracellular cytokines IFNgamma, IL-2 and TNFalpha in the blood of culture positive patients compared with culture negative patients. CONCLUSIONS: Enumeration of Tregs and intracellular Th1 cytokines may provide a sensitive, specific test for determining infection in childhood oncology patients before blood culture results become available.
机译：背景：小儿肿瘤性发热性中性粒细胞减少症患者通常需住院并接受经验性广谱抗生素治疗，以降低感染风险。但是，目前尚无可用于快速识别这些患者中菌血症的方法。 T辅助1型（Th1）细胞因子是对许多病原生物有效免疫应答所必需的，而T调节细胞是已知的Th1细胞抑制剂。我们假设减少的细胞内Th1细胞因子和增加的T调节细胞（Tregs）的表征可能被证明可用于确定儿童期肿瘤性发热性中性粒细胞减少症的感染。方法：采用多参数流式细胞术对一组儿童肿瘤性发热性中性粒细胞减少症患者的外周血中的细胞内Th 1细胞因子和Tregs进行计数。结果：培养阳性患者血液中CD25（+）CD127（-）CD8（-）CD3（+）Tregs的百分比显着增加，Th1细胞内细胞因子IFNgamma，IL-2和TNFalpha显着降低与培养阴性患者相比。结论：在获得血液培养结果之前，枚举Treg和细胞内Th1细胞因子可能为确定儿童肿瘤患者的感染提供灵敏，特异的检测方法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号