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首页> 外文期刊>Cytokine >Interleukin-21 - A biomarker of importance in predicting myocardial function following acute infarction?
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Interleukin-21 - A biomarker of importance in predicting myocardial function following acute infarction?

机译：Interleukin-21-在预测急性梗死后心肌功能方面重要的生物标志物？

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Introduction: Following acute myocardial infarction (AMI), the acute inflammatory response contributes to wound healing but also to progressive myocardial injury. Interleukin-21 (IL-21) plays a key role in immunoregulation; whether IL-21 is associated with left ventricular (LV) remodelling after AMI is unknown. Methods: Plasma IL-21 concentrations were measured in 100 patients (age 58.9 ± 12.0. years, 77% male) admitted with AMI and LV dysfunction, at baseline (mean 46. h) and again at 24. weeks; cardiac magnetic resonance and measurement of B-type natriuretic peptide, monocyte chemoattractant protein-1, matrix metalloproteinase (MMP)-2, -3, -9, and tissue inhibitor of metalloproteinase (TIMP)-1, -2, -4 occurred at both time-points. Remodelling was defined as change in LV end-systolic volume index (ΔLVESVI). Results: Plasma IL-21 concentration was unchanged over time (48.1 [SD 35.4]. pg/mL at baseline vs. 48.8 [61.3]. pg/mL at 24. weeks, p=0.92). Baseline IL-21 correlated significantly with ΔLVESVI (r=0.30, p=0.005) and change in LV end-diastolic volume index (r=0.33, p=0.003). On multivariate analysis, plasma IL-21 was an independent predictor of remodelling. IL-21 was also significantly associated with higher TIMP-4 concentrations and lower MMP-9 concentrations at baseline. Conclusions: IL-21 predicts adverse remodelling following AMI in patients with LV dysfunction. Whether it plays a direct pathophysiological role in remodelling merits further study.
机译：简介：急性心肌梗塞（AMI）之后，急性炎症反应不仅有助于伤口愈合，而且还有助于进行性心肌损伤。白细胞介素21（IL-21）在免疫调节中起关键作用。 IL-21是否与AMI后左心室重构有关。方法：在基线时（平均46. h）和24.周时，对100例患有AMI和LV功能障碍的患者（年龄58.9±12.0。岁，男性77％）进行了血浆IL-21浓度的测量。发生于心脏的磁共振波及B型利钠肽，单核细胞趋化蛋白-1，基质金属蛋白酶（MMP）-2，-3，-9和金属蛋白酶组织抑制剂（TIMP）-1，-2，-4的测定两个时间点。重塑定义为左室收缩末期容积指数（ΔLVESVI）的变化。结果：血浆IL-21浓度随时间变化（基线时为48.1 [SD 35.4]。pg / mL，而24周时为48.8 [61.3]。pg / mL，p = 0.92）。基线IL-21与ΔLVESVI（r = 0.30，p = 0.005）和LV舒张末期容积指数的变化（r = 0.33，p = 0.003）显着相关。在多变量分析中，血浆IL-21是重塑的独立预测因子。 IL-21与基线时较高的TIMP-4浓度和较低的MMP-9浓度也显着相关。结论：IL-21可预测LV功能障碍患者在AMI后发生不良重塑。它是否在重塑中起直接病理生理作用，值得进一步研究。

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