IRF7, a functional factor associates with systemic lupus erythematosus

XuW.-D.; ZhangY.-J.; XuK.; ZhaiY.; LiB.-Z.; PanH.-F.; YeD.-Q.

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IRF7, a functional factor associates with systemic lupus erythematosus

机译：IRF7，一种功能性因子，与系统性红斑狼疮有关

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Systemic lupus erythematosus is an autoimmune disease attributing to a combination of genetic and environmental factors. Abnormal expression/function of type I interferons has been demonstrated with the pathogenesis of SLE, especially IFN-α, which can be regulated by IFN regulatory factor 7 (IRF7). Single nucleotide polymorphisms (SNPs) near/in IRF7 have been substantiated related to onset of SLE, moreover, regulation of IRF7 expression/function has been found important in SLE. Therefore, we will discuss the association of IRF7 and SLE based on recent understandings to render more information about the mechanisms of IRF7 might perform in.

机译：系统性红斑狼疮是一种自身免疫性疾病，归因于遗传和环境因素。 SLE，尤其是IFN-α的发病机制已证明I型干扰素的异常表达/功能，其可被IFN调节因子7（IRF7）调节。已经证实IRF7附近/中的单核苷酸多态性（SNP）与SLE的发作有关，此外，已经发现IRF7表达/功能的调节在SLE中很重要。因此，我们将基于最近的理解来讨论IRF7与SLE的关联，以提供有关IRF7可能发挥作用的更多信息。

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《Cytokine》 |2012年第3期|共4页
作者
XuW.-D.; ZhangY.-J.; XuK.; ZhaiY.; LiB.-Z.; PanH.-F.; YeD.-Q.;
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正文语种 eng
中图分类细胞生物学;
关键词
Autoimmune; Interferon regulatory factor 7; Systemic lupus erythematosus;

机译：自身免疫;干扰素调节因子7;系统性红斑狼疮;

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1. IRF7, a functional factor associates with systemic lupus erythematosus [J] . XuW.-D., ZhangY.-J., XuK., Cytokine . 2012,第3期

机译：IRF7，一种功能性因子，与系统性红斑狼疮有关
2. Association between functional IRF7 variant and systemic lupus erythematosus may need more critical examination: Comment on the article by Fu et al [J] . Fang Wang MD Yan-Feng Zou MD Guo-Ping Sun MD Arthritis & Rheumatism . 2011,第10期

机译：功能性IRF7变异与系统性红斑狼疮之间的关联可能需要更严格的检查：对Fu等人文章的评论
3. Association between functional IRF7 variant and systemic lupus erythematosus may need more critical examination: comment on the article by Fu et al. [J] . Wang F, Zou YF, Sun GP Arthritis and Rheumatism . 2011,第10期

机译：功能性IRF7变异与系统性红斑狼疮之间的关联可能需要更严格的检查：对Fu等人文章的评论。
4. Traditional versus nontraditional risk factors of atherosclerosis in patients with systemic lupus erythematosus [C] . Fischer K, Walecka A, Sawicki M, International Congress on Coronary Artery Disease . 2011

机译：系统性红斑狼疮患者动脉粥样硬化的传统与非传统风险因素
5. Awareness of increased risk for heart disease and cardiovascular risk factors in women with systemic lupus erythematosus. [D] . Weinstein, Patricia K. 2009

机译：意识到系统性红斑狼疮妇女患心脏病和心血管危险因素的风险增加。
6. Association of a functional IRF7 variant with systemic lupus erythematosus [O] . Qiong Fu, Jian Zhao, Xiaoxia Qian, -1

机译：系统性红斑狼疮的功能IRF7变种协会
7. Association of a functional IRF7 variant with systemic lupus erythematosus [O] . Hahn, BH, Fu, Q, Zhao, J, 2011

机译：功能性IRF7变体与系统性红斑狼疮的关联

IRF7, a functional factor associates with systemic lupus erythematosus

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