Association of IL-4 receptor gene polymorphisms with high density lipoprotein cholesterol

ChangY.-H.; HuangC.-N.; ShiauM.-Y.

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Association of IL-4 receptor gene polymorphisms with high density lipoprotein cholesterol

机译：IL-4受体基因多态性与高密度脂蛋白胆固醇的关系

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The aim of this study is to investigate the correlation between E400A polymorphisms of interleukin-4 receptor α chain (IL-4Rα) and lipid metabolism. Genomic DNA from 121 type 2 diabetes mellitus (T2DM) patients and 113 non-diabetic, non-obese control study subjects were extracted, and their IL-4Rα E400A polymorphisms were analyzed by PCR-RFLP. The correlation between IL-4Rα E400A genotypes and study subjects' lipid profile was then examined. Significant associations of the IL-4Rα E400A genotypes and high density lipoprotein-cholesterol (HDL-C) levels among control individuals (p= 0.007), as well as among the T2DM patients (p= 0.029), were observed. Significant correlations between IL-4Rα E400A genotypes with blood pressure, as well as with blood urea nitrogen, were also observed in control subjects. Our results reveal that IL-4Rα may play certain roles in the lipid metabolism of Taiwanese population and suggest a novel link between lipid metabolism and the cytokine receptor.

机译：本研究的目的是研究白介素4受体α链（IL-4Rα）的E400A多态性与脂质代谢之间的关系。提取了来自121位2型糖尿病（T2DM）患者和113位非糖尿病，非肥胖对照研究对象的基因组DNA，并通过PCR-RFLP分析了其IL-4RαE400A多态性。然后检查了IL-4RαE400A基因型与研究对象脂质状况之间的相关性。在对照个体（p = 0.007）以及T2DM患者（p = 0.029）中观察到IL-4RαE400A基因型与高密度脂蛋白胆固醇（HDL-C）水平的显着关联。在对照受试者中还观察到IL-4RαE400A基因型与血压以及血液尿素氮之间的显着相关性。我们的研究结果表明，IL-4Rα可能在台湾人群的脂质代谢中起一定作用，并暗示脂质代谢与细胞因子受体之间存在新的联系。

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《Cytokine》 |2012年第2期|共4页
作者
ChangY.-H.; HuangC.-N.; ShiauM.-Y.;
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正文语种 eng
中图分类细胞生物学;
关键词
High density lipoprotein-cholesterol; Interleukin-4; Interleukin-4 receptor; Lipid metabolism;

机译：高密度脂蛋白胆固醇;白介素4;白介素4受体;脂质代谢;

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1. Association of IL-4 receptor gene polymorphisms with high density lipoprotein cholesterol [J] . ChangY.-H., HuangC.-N., ShiauM.-Y. Cytokine . 2012,第2期

机译：IL-4受体基因多态性与高密度脂蛋白胆固醇的关系
2. Association between Angiotensin II Type 2 Receptor Gene A/C3123 Polymorphism and High-Density Lipoprotein Cholesterol with Hypertension in Asymptomatic Women [J] . Kotani K., Sakane N., Taniguchi N. Medical principles and practice: international journal of the Kuwait University, Health Science Centre . 2013,第1期

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3. Association between Angiotensin II Type 2 Receptor Gene A/C3123 Polymorphism and High-Density Lipoprotein Cholesterol with Hypertension in Asymptomatic Women [J] . Kotani K., Sakane N., Taniguchi N. Medical principles and practice: international journal of the Kuwait University, Health Science Centre . 2012,第1期

机译：无症状女性高血压中血管紧张素II 2型受体基因A / C3123多态性与高密度脂蛋白胆固醇与高血压的关系
4. Association of Vitamin D Receptor Gene Polymorphism and Bone Mineral Density: An Analysis by Possibility Theory [C] . Shih-Chuan Cheng, D. S. Malik, John N. Mordeson, World Multiconference on Systemics, Cybernetics and Informatics and 5th International Conference on Information Systems Analysis and Synthesis Vol.8: Concepts and applications of Systemics, Cybernetics and Informatics, Jul 31-Aug 4, 1999, Orlando, Flor . 1999

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6. Association between Angiotensin II Type 2 Receptor Gene A/C3123 Polymorphism and High-Density Lipoprotein Cholesterol with Hypertension in Asymptomatic Women [O] . Kazuhiko Kotani, Naoki Sakane, Nobuyuki Taniguchi 2012

机译：无症状妇女高血压中血管紧张素II 2型受体基因A / C3123多态性与高密度脂蛋白胆固醇与高血压的关系
7. Changes in plasma low-density lipoprotein (LDL)- and high-density lipoprotein cholesterol in hypo- and hyperthyroid patients are related to changes in free thyroxine, not to polymorphisms in LDL receptor or cholesterol ester transfer protein genes [O] . Diekman, M. J., Anghelescu, N., Endert, E., 2000

机译：甲状腺功能低下和甲状腺功能亢进患者的血浆低密度脂蛋白（LDL）和高密度脂蛋白胆固醇的变化与游离甲状腺素的变化有关，与LDL受体或胆固醇酯转移蛋白基因的多态性无关

Association of IL-4 receptor gene polymorphisms with high density lipoprotein cholesterol

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