MARCH1 down-regulation in IL-10-activated B cells increases MHC class II expression

GalbasT.; SteimleV.; LapointeR.; IshidoS.; ThibodeauJ.

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MARCH1 down-regulation in IL-10-activated B cells increases MHC class II expression

机译：IL-10-激活的B细胞中的MARCH1下调增加了MHC II类表达

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IL-10 is vastly studied for its anti-inflammatory properties on most immune cells. However, it has been reported that IL-10 activates B cells, up-regulates their MHC class II molecules and prevents apoptosis. As MARCH1 was shown to be responsible for the intracellular sequestration of MHC class II molecules in dendritic cells and monocytes in response to IL-10, we set out to clarify the role of this ubiquitin ligase in B cells. Here, we demonstrate in mice that splenic follicular B cells represent the major cell population that up-regulate MHC II molecules in the presence of IL-10. Activation of these cells through TLR4, CD40 or the IL-10 receptor caused the down-regulation of MARCH1 mRNA. Accordingly, B cells from MARCH1-deficient mice do not up-regulate I-A b in response to IL-10. In all, our results demonstrate that IL-10 can have opposite effects on MARCH1 regulation in different cell types.

机译：IL-10对大多数免疫细胞的抗炎特性已得到广泛研究。然而，据报道IL-10激活B细胞，上调其MHC II类分子并阻止细胞凋亡。由于显示MARCH1负责树突状细胞和单核细胞对IL-10的MHC II类分子的细胞内螯合，我们着手阐明这种泛素连接酶在B细胞中的作用。在这里，我们在小鼠中证明脾滤泡B细胞代表在IL-10存在下上调MHC II分子的主要细胞群。这些细胞通过TLR4，CD40或IL-10受体的激活导致MARCH1 mRNA的下调。因此，来自MARCH1缺陷型小鼠的B细胞不响应IL-10而上调I-A b。总之，我们的结果表明，IL-10在不同细胞类型中对MARCH1调控具有相反的作用。

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《Cytokine》 |2012年第1期|共4页
作者
GalbasT.; SteimleV.; LapointeR.; IshidoS.; ThibodeauJ.;
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正文语种 eng
中图分类细胞生物学;
关键词
B cells; IL-10; MARCH1; MHC-II; Ubiquitin;

机译：B细胞;IL-10;MARCH1;MHC-II;泛素;

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专利

1. MARCH1 down-regulation in IL-10-activated B cells increases MHC class II expression [J] . GalbasT., SteimleV., LapointeR., Cytokine . 2012,第1期

机译：IL-10-激活的B细胞中的MARCH1下调增加了MHC II类表达
2. Absence of MHC class II antigen expression in trophoblast cells results from a lack of class II transactivator (CIITA) gene expression [J] . SHAWN P. MURPHY, THOMAS B. TOMASI Molecular reproduction and development . 1998,第1期

机译：滋养层细胞中缺乏MHC II类抗原表达是由于缺乏II类反式激活因子（CIITA）基因表达引起的
3. Down-Regulation of MHC Class II Expression through Inhibition of CIITA Transcription by Lytic Transactivator Zta during Epstein-Barr Virus Reactivation [J] . Dan Li, Lu Qian, Changguo Chen, The journal of immunology . 2009,第4期

机译：在爱泼斯坦-巴尔病毒重新激活过程中，通过抑制裂解液Zta的CIITA转录来下调MHC II类表达。
4. TAP expression level in tumor cells defines the nature and processing of MHC class I peptides for recognition by tumor-specific cytotoxic T lymphocytes [C] . Faten El Hage, Aurélie Durgeau, Fathia Mami-Chouaib Federation of Immunological Societies of Asia-Oceania. . 2013

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5. Modulation of IFN-gamma-induced MHC class II gene expression in human vascular endothelial cells by Porphyromonas gingivalis membrane vesicles. [D] . Srisatjaluk, Ratchapin Laovanit. 2001

机译：牙龈卟啉单胞菌膜囊泡对人血管内皮细胞中IFN-γ诱导的MHC II类基因表达的调节。
6. MHC Class II–Alpha Chain Knockout Mice Support Increased Viral Replication That Is Independent of Their Lack of MHC Class II Cell Surface Expression and Associated Immune Function Deficiencies [O] . Mohammed Alsharifi, Aulikki Koskinen, Danushka K. Wijesundara, -1

机译：MHC II类– Alpha链敲除小鼠支持增加的病毒复制这与其缺乏MHC II类细胞表面表达和相关的免疫功能缺陷无关
7. Francisella tularensis Elicits IL-10 via a PGE2-Inducible Factor, to Drive Macrophage MARCH1 Expression and Class II Down-Regulation [O] . Hunt, Danielle, Wilson, Justin E., Weih, Karis A., 2012

机译：图拉弗朗西斯菌通过PGE2诱导因子诱导IL-10，以驱动巨噬细胞MARCH1表达和II类下调

MARCH1 down-regulation in IL-10-activated B cells increases MHC class II expression

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