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Umbilical artery chemokine CCL16 is associated with preterm preeclampsia and fetal growth restriction

机译：脐动脉趋化因子CCL16与早产先兆子痫和胎儿生长受限有关

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Background: Cytokines and growth factors synthesized by placental trophoblasts are suggested to induce endothelial and vascular smooth muscle cell apoptosis and affect angiogenesis. Objective: To investigate cord blood and placental immunoproteins in order to find new clues on pathogenetic factors of preterm preeclampsia. Methods: Cord blood samples were collected on 163 consecutive preterm deliveries prior to 32 gestational weeks. Placental function, clinical risk factors and 107 umbilical artery immunoproteins were analyzed. Classification and regression trees analysis was used to detect associations between the immunoproteins, clinical parameters and preterm preeclampsia. Placental expression of the immunoproteins and their receptors were subsequently investigated. Results: Preeclampsia complicated 34% of the pregnancies in this preterm cohort. Umbilical artery CCL16, CCL24, and CCL23 were associated with preeclampsia, CCL16 showing the strongest relationship with an OR (95% CI) of 24.5 (5.4-112.0). High umbilical artery CCL16 was also characteristic to fetuses with severe growth restriction (<3rd percentile). CCL16, CCL24 and their receptors, CCR1 and CCR3 were expressed in preeclamptic placentas. Conclusions: High umbilical artery CCL16 is prominently detected in preterm preeclamptic pregnancies with severe growth restriction. A link to compensatory proangiogenic mechanisms has to be considered.
机译：背景：胎盘滋养细胞合成的细胞因子和生长因子被认为可诱导内皮和血管平滑肌细胞凋亡并影响血管生成。目的：研究脐带血和胎盘免疫蛋白，为早产先兆子痫的致病因素提供新的线索。方法：在32个孕周前连续163次早产采集脐血。分析胎盘功能，临床危险因素和107种脐动脉免疫蛋白。分类和回归树分析用于检测免疫蛋白，临床参数和早产先兆子痫之间的关联。随后研究了免疫蛋白及其受体的胎盘表达。结果：在该早产儿队列中，先兆子痫使34％的妊娠复杂化。脐动脉CCL16，CCL24和CCL23与先兆子痫相关，CCL16与OR（95％CI）为24.5（5.4-112.0）的关系最密切。高脐动脉CCL16也是具有严重生长限制（<3％百分位）的胎儿的特征。 CCL16，CCL24及其受体CCR1和CCR3在先兆子痫胎盘中表达。结论：早产先兆子痫孕妇中明显检测到高脐动脉CCL16，且生长受限。必须考虑与代偿性促血管生成机制的联系。

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