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首页> 外文期刊>Cytokine >Respiratory distress syndrome (RDS) in premature infants is underscored by the magnitude of Th1 cytokine polarization
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Respiratory distress syndrome (RDS) in premature infants is underscored by the magnitude of Th1 cytokine polarization

机译：Th1细胞因子极化的强度突出了早产儿的呼吸窘迫综合征（RDS）

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Respiratory distress syndrome (RDS) is a common problem and the leading cause of death in premature infants (PI). The introduction of surfactant treatment for RDS management has lowered mortality and morbidity; nevertheless, some neonates do not improve and are at increased risk of pulmonary hemorrhage. Inflammation, not only local but also systemic, seems to play an important role in the pathogenesis of RDS. To determine whether cytokine patterns characterize RDS and its outcome, we measured type-1 (IL-2, TNF-α, IFN-γ, IL-6) and type-2 (IL-4, IL-5, IL-10, TGF-β1) serum cytokines of 47 PI with established RDS and a control group of 30 healthy, appropriate for gestational age, full-term neonates. Cord blood samples were obtained at the time of delivery from PI and controls. Venous blood samples were collected from PI who received surfactant treatment and/or developed pulmonary hemorrhage. Significantly elevated cord blood cytokine levels were observed in PI at time of delivery, compared to controls, except for IL-5 and TNF-α levels that were within control range. The type-1/type-2 cytokine ratio was significantly increased in PI vs controls. Neonates who developed pulmonary hemorrhage between 2 and 3. days of life and/or died, presented the strongest Th1 and type-1 cytokine polarization that was mainly due to increased IFN-γ and TNF-α, and decreased TGF-β1. The majority of these PI were female with very low gestational age. Overall, PI with RDS present a Th1/type-1 cytokine polarization, which persists irrespective of the treatment provided, and is amplified when complications appear. Th1 polarization is associated with poor prognosis.
机译：呼吸窘迫综合征（RDS）是常见问题，是早产婴儿（PI）的主要死亡原因。为RDS管理引入表面活性剂治疗降低了死亡率和发病率。然而，一些新生儿并没有改善，并且患肺出血的风险增加。炎症，不仅是局部的，而且是全身的，在RDS的发病机理中似乎起着重要作用。为了确定细胞因子模式是否表征RDS及其结果，我们测量了1型（IL-2，TNF-α，IFN-γ，IL-6）和2型（IL-4，IL-5，IL-10， TGF-β1）47个PI的血清细胞因子，已建立RDS，对照组为30个健康的，适合胎龄的足月新生儿。脐带血样品在分娩时从PI和对照中获得。从接受表面活性剂治疗和/或发生肺出血的PI收集静脉血样。与对照组相比，分娩时在PI中观察到脐血细胞因子水平显着升高，但IL-5和TNF-α的水平在对照组范围内。与对照组相比，PI中的1型/ 2型细胞因子比率显着增加。在出生后2至3天之内发生肺出血和/或死亡的新生儿表现出最强的Th1和1型细胞因子极化，这主要归因于IFN-γ和TNF-α的增加以及TGF-β1的降低。这些PI中的大多数是胎龄很低的女性。总体而言，具有RDS的PI表现出Th1 / type-1细胞因子极化，无论提供何种治疗均持续存在，并在出现并发症时被放大。 Th1极化与不良预后有关。

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