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首页> 外文期刊>Cytokine >Serum levels of inflammation factors and cognitive performance in amnestic mild cognitive impairment: A Chinese clinical study
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Serum levels of inflammation factors and cognitive performance in amnestic mild cognitive impairment: A Chinese clinical study

机译：遗忘性轻度认知障碍患者血清炎症因子水平和认知能力的临床研究

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摘要

Early diagnosis of Alzheimer's disease (AD) is important for initiating timely therapy to block or slow the rate of disease progression. This study was designed to investigate the potential of inflammation-related biomarkers in peripheral blood to accurately reflect AD onset and progression. Individuals (n= 150) with amnestic mild cognitive impairment (aMCI) were divided into two subgroups (low- and high-risk) based on APOEε4 allele carrier status, and administered a battery of neuropsychological tests and tested for serum levels of IL-6, IL-10, TNF-α, and IFN-γ by using specific enzyme-linked immunosorbent assays. Results were compared with those from age-matched healthy controls (n=150). The levels of IL-6 were significantly higher in the aMCI group than in controls (P< 0.01). When the aMCI group was stratified by APOEε4 status, significant differences were found between the low- and high-risk groups and controls in the levels of IL-6 and IFN-γ (P< 0.01 and P=0.041, respectively). Moreover, the IL-6 level in the low-risk aMCI group was higher than that in the high-risk aMCI group (P=0.028). A weak but significant negative correlation was found between IL-6 and cognitive performance. Taken together, these findings indicate that IL-6, while not useful alone, has potential in combination with other biomarkers to support early diagnosis of aMCI due to its association with the progression of cognitive impairment.
机译：阿尔茨海默氏病（AD）的早期诊断对于启动及时治疗以阻止或减慢疾病进展的速度非常重要。本研究旨在研究外周血中与炎症相关的生物标志物准确反映AD发作和进展的潜力。根据APOEε4等位基因携带者的状况，将遗忘性轻度认知障碍（aMCI）的个体（n = 150）分为两个亚组（低风险和高风险），并进行了一系列神经心理学测试并测试了血清IL-6水平，IL-10，TNF-α和IFN-γ的检测采用了特定的酶联免疫吸附试验。将结果与年龄匹配的健康对照组（n = 150）进行了比较。 aMCI组的IL-6水平显着高于对照组（P <0.01）。当aMCI组按APOEε4状态分层时，在低危和高危组与对照组之间，IL-6和IFN-γ的水平存在显着差异（分别为P <0.01和P = 0.041）。此外，低风险aMCI组的IL-6水平高于高风险aMCI组（P = 0.028）。 IL-6与认知能力之间存在弱但显着的负相关。综上所述，这些发现表明，IL-6虽然不能单独使用，但由于与认知障碍的发展相关，因此有可能与其他生物标志物联合用于支持aMCI的早期诊断。

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