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首页> 外文期刊>Cytokine >Association of IL-6 polymorphisms with gastric cancer risk: Evidences from a meta-analysis
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Association of IL-6 polymorphisms with gastric cancer risk: Evidences from a meta-analysis

机译：IL-6基因多态性与胃癌风险的关联：荟萃分析的证据

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The findings of associations between IL-6 polymorphisms and risk of gastric cancer are controversial. We conducted a meta-analysis of the IL-6 gene to provide evidences for the current understanding of the genetic association with gastric cancer. We searched for relevant studies without language restriction in PubMed, EMBASE and Cochrane Library published up to November 2011. The strengths of the associations between IL-6 polymorphisms and gastric cancer risk were estimated by odds ratios (OR) with 95% confidence interval (95% CI). We identified seven case-control studies involving 1364 gastric cancer cases and 1748 controls for the analysis. Because of limited eligible data, our meta-analysis specifically focused on three SNPs of the IL-6 gene, -174 G/C, -572 G/C and -597 G/A. We found no significant associations of IL-6-174 G/C, -572 G/C and -597 G/A polymorphisms with gastric cancer risk in the overall population (all p> 0.05). Subgroup analysis did not show significant associations in Asian population or Caucasian population either (all p> 0.05). Begg's test and Egger's test suggested no evidence of publication (all p> 0.05). Our findings showed that polymorphisms of IL-6-174 G/C, -572 G/C and -597 G/A are not associated with gastric cancer risk. However, the results should be interpreted with caution due to the limited number of studies available.
机译：IL-6基因多态性与胃癌风险之间的关联性发现存在争议。我们对IL-6基因进行了荟萃分析，为当前对与胃癌遗传相关性的了解提供了证据。我们在截至2011年11月的PubMed，EMBASE和Cochrane图书馆中搜索了无语言限制的相关研究。IL-6多态性与胃癌风险之间的关联强度是通过比值比（OR）和95％置信区间（95）来估计的。 ％CI）。我们确定了七个病例对照研究，涉及1364例胃癌病例和1748例对照进行分析。由于有限的合格数据，我们的荟萃分析专门针对IL-6基因的三个SNP，即-174 G / C，-572 G / C和-597 G / A。我们发现IL-6-174 G / C，-572 G / C和-597 G / A多态性与总人群中胃癌风险没有显着相关性（所有p> 0.05）。亚组分析也没有显示出在亚洲人口或高加索人口中的显着关联（所有p> 0.05）。 Begg检验和Egger检验表明没有发表证据（所有p> 0.05）。我们的研究结果表明，IL-6-174 G / C，-572 G / C和-597 G / A的多态性与胃癌风险无关。但是，由于可用研究数量有限，因此应谨慎解释结果。

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