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首页> 外文期刊>Cytokine >Soluble ST2 as a marker of disease activity in systemic juvenile idiopathic arthritis
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Soluble ST2 as a marker of disease activity in systemic juvenile idiopathic arthritis

机译：可溶性ST2作为系统性幼年特发性关节炎疾病活动的标志

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摘要

To assess the role of interleukin (IL)-33 and ST2, the receptor for IL-33, in the pathogenesis of systemic juvenile idiopathic arthritis (s-JIA), we sequentially measured the serum levels of IL-33 and soluble ST2 (sST2) in patients with s-JIA and determined their correlation with measures of disease activity and severity. Twenty-four patients with s-JIA, 5 with rheumatoid factor positive polyarticular JIA (RF. +. poly-JIA), and 20 age-matched healthy controls (HCs) were analyzed. IL-33 and sST2 levels were quantified in serum by enzyme-linked immunosorbent assays. Serum IL-33 levels in most patients with active s-JIA were below the lowest detection limit. Serum IL-33 levels in patients with RF. +. poly-JIA were significantly higher than those in patients with s-JIA and HC. Serum sST2 levels in patients during the active phase of s-JIA were much higher than those in patients with poly-JIA and HC. Serum sST2 levels in patients with s-JIA were significantly elevated even in the inactive phase, when other clinical parameters were normalized. Serum sST2 levels correlated positively with the clinical parameters of disease activity. These findings indicate that ST2 may be an important mediator in s-JIA. Serum sST2 levels in patients with s-JIA correlated with disease activity, suggesting a potential role as a promising indicator of disease activity.
机译：为了评估白介素（IL）-33和IL-33的受体ST2在系统性幼年特发性关节炎（s-JIA）发病机理中的作用，我们依次测量了血清IL-33和可溶性ST2（sST2） s-JIA患者），并确定其与疾病活动性和严重程度的相关性。分析了24例s-JIA，5例类风湿因子阳性多关节JIA（RF。+。poly-JIA）和20例年龄匹配的健康对照（HCs）患者。通过酶联免疫吸附测定定量血清中的IL-33和sST2水平。大多数活动性s-JIA患者的血清IL-33水平低于最低检出限。 RF患者的血清IL-33水平。 +。 poly-JIA明显高于s-JIA和HC患者。 s-JIA活动期患者的血清sST2水平远高于poly-JIA和HC患者。 s-JIA患者的血清sST2水平显着升高，即使在其他临床参数正常化的非活动期也是如此。血清sST2水平与疾病活动的临床参数呈正相关。这些发现表明ST2可能是s-JIA的重要介体。 s-JIA患者的血清sST2水平与疾病活动相关，表明其可能作为疾病活动的有希望的指标。

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