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首页> 外文期刊>Cytokine >Maintenance of CMV-specific CD8+ T cell responses and the relationship of IL-27 to IFN-?? levels with aging
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Maintenance of CMV-specific CD8+ T cell responses and the relationship of IL-27 to IFN-?? levels with aging

机译：维持CMV特异性CD8 + T细胞应答以及IL-27与IFN-α的关系随着年龄的增长

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We investigated whether healthy young (age??40) and elderly (age??65) people infected with cytomegalovirus (CMV) had similar levels of CD8+ T cell cytokine production and proliferation in response to an immunodominant CMV pp65 peptide pool given the role of CD8+ T cells in controlling viral infection and the association of CMV with immunosenescence. Plus, we determined the effects of aging and CMV-infectious status on plasma levels of IL-27, an innate immune cytokine with pro- and anti-inflammatory properties, as well as on its relationship to IFN-?? in that IL-27 can promote the production of IFN-??. The results of our study show that young and elderly people had similar levels of CD8+ T cell proliferation, and IFN-?? and TNF-?? production in response to CMV pp65 peptides. Plasma levels of IL-27 were similar between the two groups although CMV-infected young and elderly people had a trend toward increased levels of IL-27. Regardless of aging and CMV-infectious status, plasma levels of IL-27 correlated highly with plasma levels of IFN-??. These findings suggest the maintenance of CMV pp65-specific CD8+ T cell proliferation and cytokine production with aging as well as the sustaining of circulatory IL-27 levels and its biological link to IFN-?? in young and elderly people irrespective of CMV infection. ? 2012 Elsevier Ltd.
机译：我们调查了感染巨细胞病毒（CMV）的健康的年轻人（年龄在40岁以下）和老年人（年龄在65岁以上）是否对CD8 + T细胞细胞因子的产生和增殖具有类似水平的反应，并赋予了CMV pp65免疫显性肽库一定的作用。 CD8 + T细胞可控制病毒感染以及CMV与免疫衰老的关系。另外，我们确定了衰老和CMV感染状态对血浆IL-27水平的影响，IL-27是一种具有促炎和抗炎特性的先天免疫细胞因子，还涉及其与IFN-γ的关系。 IL-27可以促进IFN-α的产生。我们的研究结果表明，年轻人和老年人的CD8 + T细胞增殖和IFN-γ水平相似。和TNF-α？响应CMV pp65肽生产。两组之间的血浆IL-27水平相似，尽管感染了CMV的年轻人和老年人都有升高IL-27水平的趋势。无论衰老和CMV感染状态如何，IL-27的血浆水平与IFN-γ的血浆水平高度相关。这些发现表明，随着年龄的增长，CMV pp65特异性CD8 + T细胞增殖和细胞因子的产生得以维持，循环IL-27的维持水平及其与IFN-α的生物学联系。不论CMV感染情况如何，均可在年轻人和老年人中使用。 ？ 2012爱思唯尔有限公司

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