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首页> 外文期刊>Cytokine >TGFβ/Smad signalling in psoriatic epidermis models exposed to salt water soaks and narrowband ultraviolet B radiation
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TGFβ/Smad signalling in psoriatic epidermis models exposed to salt water soaks and narrowband ultraviolet B radiation

机译：暴露于盐水浸泡和窄带紫外线B辐射的银屑病表皮模型中的TGFβ/ Smad信号传导

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The role of transforming growth factor-β1 (TGFβ1) and Smad signalling has not been established in psoriasis treatment. We aimed to investigate the effect of combined treatment with salt water soaks and ultraviolet radiation on the expression of TGFβ1/Smad signalling proteins in a psoriatic model. We studied mRNA expression (real-time RT-PCR) of TGFβ1, TGFβ receptor type I (TGFβRI), Smad2, Smad3, Smad4, Smad7, minichromosome maintenance protein 7, and involucrin in normal as well as psoriatic epidermis models (PEM) which were treated for three consecutive days with differently concentrated salt water solutions [(3% NaCl; 30% NaCl, 30% Dead Sea salt water (DSSW)] and subsequent narrowband ultraviolet B (NB-UVB). In PEM, TGFβ1 and Smad3 was significantly increased as compared to normal epidermis models. By contrast, TGFβRI mRNA was significantly decreased in PEM. Significant increase of mRNA levels of TGFβ1, TGFβRI, Smad2 and Smad3 was predominantly observed in non-irradiated and irradiated PEM pre-treated with 30% NaCl and/or DSSW which was paralleled by increase of involucrin mRNA. In PEM pre-treated with DSSW, TGFβRI, Smad2, Smad3, Smad4, and Smad7 mRNA was significantly higher in irradiated PEM when compared to non-irradiated samples. It has been shown that TGFβ1/Smad signalling is altered in a psoriatic model and may play a role in the mode of action of salt water soaks and NB-UVB phototherapy of psoriasis.
机译：在牛皮癣治疗中尚未确立转化生长因子-β1（TGFβ1）和Smad信号传导的作用。我们旨在研究牛皮癣模型中盐水浸泡和紫外线辐射联合处理对TGFβ1/ Smad信号蛋白表达的影响。我们研究了正常和银屑病表皮模型（PEM）中TGFβ1，I型TGFβ受体（TGFβRI），Smad2，Smad3，Smad4，Smad7，微染色体维持蛋白7和总蛋白的mRNA表达（实时RT-PCR），其中用不同浓度的盐水溶液[（3％NaCl; 30％NaCl，30％死海盐水（DSSW）]和随后的窄带紫外线B（NB-UVB）处理三天。在PEM中，TGFβ1和Smad3为相比之下，PEM中TGFβRImRNA的表达显着下降，而在30％NaCl预处理的非辐照和辐照的PEM中，TGFβ1，TGFβRI，Smad2和Smad3的mRNA水平显着增加。在用DSSW预处理的PEM中，与未辐照的样品相比，辐照的PEM中的TGFβRI，Smad2，Smad3，Smad4和Smad7 mRNA显着更高。 TGFβ1/ Smad信号ng在银屑病模型中发生改变，并且可能在牛皮癣的盐水浸泡和NB-UVB光疗的作用方式中起作用。

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