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首页> 外文期刊>Cytokine >Moderate exercise training modulates cytokine profile and sleep in elderly people
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Moderate exercise training modulates cytokine profile and sleep in elderly people

机译：适度的运动训练可调节老年人的细胞因子分布和睡眠

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Aging causes several physiological alterations, including alterations in sleep. It is possible that difficulty sleeping can be exacerbated by increased inflammation in older individuals. Moderate exercise training may be a modality of non-pharmacological treatment for sleep disorders and inflammation. We aimed to assess the effects of moderate exercise training on sleep in elderly people as well as their cytokine profiles. Additionally, we examined the effect of exercise training on quality of life parameters using a SF-36 questionnaire. Twenty-two male, sedentary, healthy, elderly volunteers performed moderate training for 60. min/day, 3 days/week for 24. week at a work rate equivalent to their ventilatory aerobic threshold. The environment was kept at a temperature of 23 ± 2. °C, with a humidity of 60 ± 5%. Blood and polysomnograph were collected twice: at baseline (1. week before training began) and after 6. months of training. Training increased aerobic capacity parameters (p<0.0001), decreased REM latency (p<0.02), and decreased time awake (p<0.05). After training, the levels of IL-6 (p<0.0001) and TNF-α (p<0.0001) and the ratio of TNF-α/IL-10 (p<0.0001) were decreased, whereas IL-10 levels were increased after training (p<0.001). Furthermore, exercise training was shown to improve quality of life parameters. Our results suggest that 6. months of training can improve sleep in the elderly and is related to the anti-inflammatory effect of moderate training, which modifies cytokine profiles.
机译：衰老引起几种生理变化，包括睡眠变化。老年人发炎的加剧可能加剧睡眠困难。适度的运动训练可能是睡眠障碍和炎症的非药物治疗方式。我们旨在评估适度运动训练对老年人睡眠及其细胞因子谱的影响。此外，我们使用SF-36问卷调查了运动训练对生活质量参数的影响。 22名久坐不动，健康，老年的男性志愿者接受了相当于他们的通气有氧阈值的工作量的中度训练，锻炼时间为60分钟/天，3天/周，24周。环境温度保持在23±2°C，湿度为60±5％。采集血液和多导睡眠图两次：在基线（训练开始前1.周）和训练6个月后。训练增加了有氧运动能力参数（p <0.0001），减少了REM潜伏期（p <0.02），并减少了清醒时间（p <0.05）。训练后，IL-6（p <0.0001）和TNF-α（p <0.0001）的水平以及TNF-α/ IL-10的比率（p <0.0001）降低，而IL-10的水平在训练后升高训练（p <0.001）。此外，运动训练被证明可以改善生活质量参数。我们的研究结果表明，6个月的训练可以改善老年人的睡眠，并且与中等训练的抗炎作用有关，后者可以改变细胞因子的分布。

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