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首页> 外文期刊>Cytokine >Hypothermia caused by slow and limited-volume fluid resuscitation decreases organ damage by hemorrhagic shock
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Hypothermia caused by slow and limited-volume fluid resuscitation decreases organ damage by hemorrhagic shock

机译：缓慢而有限的液体复苏引起的体温过低可减少失血性休克对器官的损害

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Background: Hypothermia frequently occurs during fluid resuscitation of trauma victims, especially in patients with a major blood loss. Recent studies have suggested that mild hypothermia may ameliorate hemorrhagic shock (HS) induced splanchnic damage. Objective: The aim of the present study is to compare the status of body temperature and splanchnic injury under different resuscitation speeds for HS in conscious rats. Methods: Experimental study in an animal model of HS. Twenty-four male Wistar-Kyoto rats were used in the study. To mimic HS, 40% of the total blood volume was withdrawn. Fluid resuscitation was given 30. min after blood withdrawal. The rats were randomly divided into three groups; the control group, the 10-min rapid group, and the 12-h slow group. Results: Levels of blood biochemical parameters, including aspartate transferase (GOT), and alanine transferase (GPT), were measured. Levels of serum tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) were measured and levels of bronchoalveolar lavage fluid (BALF) TNF-α and nitric oxide (NO) were measured by ELISA. The lung, liver and small intestine were examined for pathological changes 48. h after HS. Conclusions: Initially slow rate resuscitation with limited-volume significantly decreased body temperature, serum GOT, GPT, TNF-α, and IL-6 levels, levels of TNF-α, and NO in BALF. Moreover, the slow group had lower injury scores in the lung, liver and small intestine than the rapid group after HS. This finding suggests that mild hypothermia induced by a slow fluid resuscitation rate with limited-volume ameliorates HS-induced splanchnic damage in conscious rats.
机译：背景：体温过低通常发生在创伤受害者的液体复苏过程中，尤其是在失血量大的患者中。最近的研究表明，轻微的体温过低可能会减轻出血性休克（HS）引起的内脏损害。目的：本研究的目的是比较不同复苏速度下清醒大鼠的体温和内脏损伤状态。方法：在HS动物模型中进行实验研究。该研究使用了24只雄性Wistar-Kyoto大鼠。为了模拟HS，抽出总血量的40％。抽血后30分钟进行液体复苏。将大鼠随机分为三组。对照组，10分钟快速组和12小时缓慢组。结果：测量了血液生化参数的水平，包括天冬氨酸转移酶（GOT）和丙氨酸转移酶（GPT）。 ELISA法测定血清肿瘤坏死因子α（TNF-α）和白细胞介素6（IL-6）的水平，支气管肺泡灌洗液（BALF）TNF-α和一氧化氮（NO）的水平。 HS后48小时检查肺，肝和小肠的病理变化。结论：最初的缓慢复苏和有限的容量可显着降低体温，BALF中的血清GOT，GPT，TNF-α和IL-6水平，TNF-α和NO水平。此外，慢组在HS后的肺，肝和小肠损伤评分低于快组。这一发现表明，缓慢的液体复苏速率和有限的容量所引起的轻度低温可以改善清醒大鼠的HS诱导的内脏损害。

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