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首页> 外文期刊>British Dental Journal: The Journal of the British Dental Association >Beyond ONJ - A review of the potential uses of bisphosphonates in dentistry
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Beyond ONJ - A review of the potential uses of bisphosphonates in dentistry

机译：超越Onj - 对牙科双膦酸盐潜在使用的审查

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摘要

There is evidence, although limited, for beneficial effects of bisphophonates (BPs) across multiple dental specialties. Within implant dentistry BP coatings have been shown to significantly increase pull out forces and bone density in animal models, and significantly increase implant stability whilst reducing marginal bone loss in humans. Adjunctive topical and systemic application of BPs during conventional periodontal treatment have shown significant improvements in probing depth and clinical attachment level in various forms of periodontal disease. Within orthodontics, BPs have been shown to significantly reduce root resorption and have benefits with respect to anchorage maintenance. Case reports have suggested the use of BPs in the management of diffuse sclerosing osteomylitis. Whilst this review highlights these potential benefits and acknowledges there are no reported cases of osteonecrosis of the jaw associated with locally applied BP, there remains a paucity of human and long-term studies exploring BPs in the context of significant clinical benefit. Further human studies are required to understand the long-term clinical outcomes of these drugs when used as primary therapeutic agents, or adjuncts to conventional treatment.
机译：有有限的证据，虽然有限，但对多种牙科专业的效果（BPS）有益效果。在植入物牙科牙科BP涂层中已被证明显着增加动物模型中的拔出力和骨密度，并且显着提高植入物稳定性，同时降低人类的边际骨质损失。在常规牙周治疗期间BPS的辅助局部和全身应用显示出各种形式的牙周病的探测深度和临床附着水平的显着改善。在正畸学中，BPS已被证明可以显着减少根部吸收，并对锚固维护有益。案例报告表明BPS在弥漫性硬化骨膜炎的管理中使用。虽然本综述凸显了这些潜在的福利，并承认没有报道的患者患者与当地申请的BP相关的颌骨骨折病例，仍然是在显着临床益处的背景下探讨了BPS的人和长期研究。需要进一步的人类研究来了解当用作常规治疗剂或常规治疗的辅助辅助时这些药物的长期临床结果。

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