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首页> 外文期刊>Cytokine >Antibodies recognizing specific Mycobacterium avium subsp. paratuberculosis's MAP3738c protein in type 1 diabetes mellitus children are associated with serum Th1 (CXCL10) chemokine
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Antibodies recognizing specific Mycobacterium avium subsp. paratuberculosis's MAP3738c protein in type 1 diabetes mellitus children are associated with serum Th1 (CXCL10) chemokine

机译：识别特定鸟分枝杆菌亚种的抗体。 1型糖尿病儿童中副肺结核的MAP3738c蛋白与血清Th1（CXCL10）趋化因子相关

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Recently Mycobacterium avium subsp. paratuberculosis (Map) was associated to type 1 diabetes mellitus (T1DM). In this study we investigated for Map presence in children affected by T1DM compared to healthy children. A pool of 212 sera from T1DM children at onset was compared to sera from 57 healthy children for humoral immune response towards the Map specific protein MAP3738c by ELISA. Serum concentrations of CXCL10 (pro-Th1) and CCL2 (pro-Th2) chemokines were also measured in both sera pool. Results showed that T1DM children had a stronger seropositivity towards MAP3738c protein compared to healthy children. Data highlighted also the correlation between serum activity of T1DM patients towards the specific protein of Map and the increase of CXCL10 concentration if compared to non-diabetic subjects. In conclusion, an immune response to Map in T1DM patients at onset was observed and this may indicate a role of the bacterium in triggering or precipitating the disease. ? 2012 Elsevier Ltd.
机译：最近鸟分枝杆菌亚种。副结核病（Map）与1型糖尿病（T1DM）相关。在这项研究中，我们调查了与健康儿童相比，受T1DM影响的儿童中Map的存在情况。通过ELISA比较了发病时来自T1DM儿童的212份血清与来自57名健康儿童的血清针对Map特异性蛋白MAP3738c的体液免疫应答。在两个血清库中也测量了CXCL10（原Th1）和CCL2（原Th2）趋化因子的血清浓度。结果显示，与健康儿童相比，T1DM儿童对MAP3738c蛋白具有更强的血清阳性。数据还突显了与非糖尿病受试者相比，T1DM患者针对Map特定蛋白的血清活性与CXCL10浓度增加之间的相关性。总之，在发病时已观察到T1DM患者对Map的免疫反应，这可能表明细菌在触发或诱发疾病中的作用。 ？ 2012爱思唯尔有限公司

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