Extensive serum biomarker analysis in patients with enterohemorrhagic Escherichia coli O111-induced hemolytic-uremic syndrome

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Extensive serum biomarker analysis in patients with enterohemorrhagic Escherichia coli O111-induced hemolytic-uremic syndrome

机译：肠出血性大肠杆菌O111引起的溶血尿毒症综合征患者的广泛血清生物标志物分析

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Proinflammatory cytokines are related to the pathogenesis of enterohemorrhagic Escherichia coli infection and hemolytic-uremic syndrome (HUS). We employed an antibody array that simultaneously detects 174 serum cytokines. We identified five serum biomarkers, namely insulin growth factor-binding protein-2, angiopoietin-2, soluble interleukin-6 receptor, soluble tumor necrosis factor receptor type II, and matrix metalloprotease protein-3 whose levels increased with the development of HUS. Furthermore, the levels of these cytokines were significantly increased in severe HUS compared with mild HUS. These cytokines might play an important role in the pathogenesis of HUS and may also be used to predict the severity of HUS.

机译：促炎细胞因子与肠出血性大肠杆菌感染和溶血性尿毒症综合征（HUS）的发病机理有关。我们采用了可同时检测174种血清细胞因子的抗体阵列。我们确定了五个血清生物标志物，即胰岛素生长因子结合蛋白2，血管生成素2，可溶性白介素6受体，可溶性肿瘤坏死因子II型受体和基质金属蛋白酶蛋白3，它们的水平随着HUS的发展而增加。此外，与轻度HUS相比，重度HUS中这些细胞因子的水平显着增加。这些细胞因子可能在HUS的发病机理中起重要作用，也可以用于预测HUS的严重程度。

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《Cytokine》 |2014年第1期|共6页
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正文语种 eng
中图分类细胞生物学;
关键词
Biomarker; Cytokine; Enterohemorrhagic; Escherichia coli; Hemolytic-uremic syndrome;

机译：生物标志物;细胞因子;肠出血;大肠杆菌;溶血尿毒综合征;

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1. Extensive serum biomarker analysis in patients with enterohemorrhagic Escherichia coli O111-induced hemolytic-uremic syndrome [J] . Cytokine . 2014,第1期

机译：肠出血性大肠杆菌O111引起的溶血尿毒症综合征患者的广泛血清生物标志物分析
2. Serum tau protein as a marker of disease activity in enterohemorrhagic Escherichia coli O111-induced hemolytic uremic syndrome [J] . Kuroda Mondo, Shimizu Masaki, Inoue Natsumi, Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry . 2015,第Null期

机译：血清tau蛋白作为肠出血性大肠杆菌O111引起的溶血性尿毒症综合征疾病活性的标志物
3. Clonal Diversity of Chilean Isolates of Enterohemorrhagic Escherichia coli from Patients with Hemolytic-Uremic Syndrome, Asymptomatic Subjects, Animal Reservoirs, and Food Products [J] . Maritza Rios, Valeria Prado, Michele Trucksis, Journal of Clinical Microbiology . 1999,第3期

机译：溶血尿毒综合征，无症状受试者，动物水库和食品的智利大肠埃希菌大肠杆菌分离株的克隆多样性
4. A study of enterohemorrhagic Escherichia coli in beef cow-calf herds in Mississippi and Nebraska [C] . Annual Conference of the American Association of Bovine Practitioners . 2017

机译：密西布拉斯加州牛肉牛犊牛群肠杆菌大肠杆菌研究
5. The Response of Salmonella enterica and Enterohemorrhagic Escherichia coli in Low-Moisture Environments [D] . Lauer, Jessica. 2021

机译：沙门氏菌肠和肠内鼠髓大肠杆菌在低湿度环境中的响应
6. Note: Clonal Diversity of Chilean Isolates of Enterohemorrhagic Escherichia coli from Patients with Hemolytic-Uremic Syndrome Asymptomatic Subjects Animal Reservoirs and Food Products [O] . Maritza Rios, Valeria Prado, Michele Trucksis, 1999

机译：注：智利溶血性尿毒症综合症无症状受试者动物水库和食品中大肠杆菌分离株的克隆多样性
7. Serum tau protein as a marker of disease activity in enterohemorrhagic Escherichia coli O111-induced hemolytic uremic syndrome [O] . Mondo Kuroda, Masaki Shimizu, Natsumi Inoue, 2015

机译：血清Tau蛋白作为肠溶性大肠杆菌o111诱导溶血性尿毒症综合征的疾病活动中的标志物
8. Secretome Biomarkers for the Identification and Differentiation of Enterohemorrhagic and Enteropathogenic Escherichia coli Strains. [R] . Jabbour, R. E., Wright, J. D., Wade, M. M., 2013

机译：用于鉴定和分化肠出血性和肠致病性大肠杆菌菌株的secretome生物标志物。

Extensive serum biomarker analysis in patients with enterohemorrhagic Escherichia coli O111-induced hemolytic-uremic syndrome

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