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首页> 外文期刊>Cytokine >c.29C > T polymorphism in the transforming growth factor-beta 1 (TGFB1) gene correlates with increased risk of urinary bladder cancer
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c.29C > T polymorphism in the transforming growth factor-beta 1 (TGFB1) gene correlates with increased risk of urinary bladder cancer

机译：c.29C>转化生长因子-β1（TGFB1）基因中的T多态性与膀胱癌风险增加相关

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TGF-beta 1 is a pleiotropic cytokine, which plays a dual role in tumor development. In the early stages, it inhibits the growth of tumor while in the late stages of carcinoma, it promotes tumor growth. The purpose of this study was to analyze the distribution of the TGFB1 gene polymorphisms between cases and controls so as to assess their correlation with bladder cancer risk. This study included 237 cases of urinary bladder cancer and 290 age matched controls from the same ethnic background. Three polymorphisms in the TGFB1 gene, c.29C>T (rs-1800470), c.74G>C (rs-1800471) and +140A>G (rs-13447341), were analyzed by direct DNA sequencing. Statistical analyses revealed no significant differences in the demographical data, except that the frequencies of smokers and non-vegetarians were higher in the cases. Eighty percent of the bladder cancer patients had superficial transitional cell carcinoma, and 53.16% and 26.31% of the patients were in grade I and grade II, respectively. We found that c.29C>T substitution increased the risk of bladder cancer significantly and recessive model of analysis was the best fitted model (p = 0.004; OR = 1.72 95% CI 1.18-2.50). A significantly higher risk in the recessive form was also suggested by co-dominant analysis showing that the homozygous form (TT) was a significant risk factor in comparison to CC and CT genotypes. The other two polymorphisms, c.74G>C (p = 0.18, OR = 0.67 95% CI 0.37-1.21) and +140A>G (p = 0.416, OR = 0.77 95% CI 0.41-1.45) did not affect the risk of urinary bladder cancer. In conclusion, we found that the TGFB1 c.29C>T substitution increases the risk of bladder cancer significantly while c.74G>C and +140A>G polymorphisms do not affect the risk. (C) 2015 Elsevier Ltd. All rights reserved.
机译：TGF-beta 1是一种多效细胞因子，在肿瘤发展中起着双重作用。在早期阶段，它抑制肿瘤的生长，而在癌晚期阶段，它促进肿瘤的生长。这项研究的目的是分析病例和对照之间TGFB1基因多态性的分布，以评估其与膀胱癌风险的相关性。这项研究包括来自同一种族背景的237例膀胱癌和290个年龄相匹配的对照组。通过直接DNA测序分析了TGFB1基因中的三个多态性，即c.29C> T（rs-1800470），c.74G> C（rs-1800471）和+ 140A> G（rs-13447341）。统计分析表明，人口统计数据无显着差异，只是吸烟者和非素食者的频率较高。膀胱癌患者中有80％患有浅表移行细胞癌，分别为I级和II级的患者分别为53.16％和26.31％。我们发现c.29C> T替代显着增加了膀胱癌的风险，隐性分析模型是最佳拟合模型（p = 0.004; OR = 1.72 95％CI 1.18-2.50）。通过共显性分析还表明隐性形式的风险显着更高，表明纯合子形式（TT）与CC和CT基因型相比是重要的危险因素。其他两个多态性c.74G> C（p = 0.18，OR = 0.67 95％CI 0.37-1.21）和+ 140A> G（p = 0.416，OR = 0.77 95％CI 0.41-1.45）不会影响风险膀胱癌。总之，我们发现TGFB1 c.29C> T替代显着增加了罹患膀胱癌的风险，而c.74G> C和+ 140A> G多态性并不影响该风险。 （C）2015 Elsevier Ltd.保留所有权利。

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