Differential alteration in peripheral T-regulatory and T-effector cells with change in P-glycoprotein expression in Childhood Nephrotic Syndrome: A longitudinal study

Prasad Narayan; Jaiswal Akhilesh K.; Agarwal Vikas; Yadav Brijesh; Sharma Raj Kumar; Rai Mohit; Singh Harshit; Chaturvedi Saurabh; Singh Ajay

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Differential alteration in peripheral T-regulatory and T-effector cells with change in P-glycoprotein expression in Childhood Nephrotic Syndrome: A longitudinal study

机译：儿童肾病综合征外周血T-调节和T-效应细胞的差异性变化与P-糖蛋白表达的变化

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Introduction: Childhood Idiopathic Nephrotic Syndrome (INS) responds to glucocorticoid therapy, however, 60-80% of patients relapse and some of them become steroid non responsive. INS may occur because of T cell dysfunction, abnormal cytokines and podocytopathies which reverse on steroid treatment. The reason of relapses could be imbalances in T cells phenotypes and respective cytokines. Herein, we hypothesize that relapses in INS may occur due to imbalance in T-regulatory and T-effector cell with their respective cytokines and overexpression of P-gp on lymphocytes.

机译：简介：儿童特发性肾病综合征（INS）对糖皮质激素治疗有反应，但是，60-80％的患者复发，其中一些患者对类固醇无反应。 INS可能是由于T细胞功能障碍，异常的细胞因子和足细胞病而发生的，这些激素在类固醇治疗后会逆转。复发的原因可能是T细胞表型和各自的细胞因子失衡。本文中，我们假设INS的复发可能是由于T调节和T效应细胞与其各自的细胞因子失衡以及淋巴细胞上P-gp的过度表达所致。

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《Cytokine》 |2015年第2期|共7页
作者
Prasad Narayan; Jaiswal Akhilesh K.; Agarwal Vikas; Yadav Brijesh; Sharma Raj Kumar; Rai Mohit; Singh Harshit; Chaturvedi Saurabh; Singh Ajay;
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正文语种 eng
中图分类细胞生物学;
关键词
Regulatory T cells; Effector T cells; Nephrotic Syndrome; P-gp expression; Relapse;

机译：调节性T细胞;效应性T细胞;肾病综合征;P-gp表达;复发;

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1. Differential alteration in peripheral T-regulatory and T-effector cells with change in P-glycoprotein expression in Childhood Nephrotic Syndrome: A longitudinal study [J] . Prasad Narayan, Jaiswal Akhilesh K., Agarwal Vikas, Cytokine . 2015,第2期

机译：儿童肾病综合征外周血T-调节和T-效应细胞的差异性变化与P-糖蛋白表达的变化
2. Gene expression profiling of peripheral blood mononuclear cells from patients with minimal change nephrotic syndrome by cDNA microarrays. [J] . Komatsuda A, Wakui H, Iwamoto K, American Journal of Nephrology . 2008,第4期

机译：通过cDNA微阵列分析来自最小变化肾病综合征患者外周血单核细胞的基因表达谱。
3. Up-regulation of TRAIL mRNA expression in peripheral blood mononuclear cells from patients with minimal-change nephrotic syndrome. [J] . Okuyama S, Komatsuda A, Wakui H, Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association . 2005,第3期

机译：微小变化性肾病综合征患者外周血单个核细胞中TRAIL mRNA表达的上调。
4. Radiosensitivity and expression of nucleotide excision repair genes in peripheral blood mononuclear cells of myelodysplastic syndrome patients [C] . Sadayuki Ban, Ken Kuramoto, Kenji Od, International Symposium of Radiation and Homeostasis . 2002

机译：髓细胞增生综合征患者外周血单核细胞中核苷酸切除修复基因的放射敏感性和表达
5. Differential expression and nuclear localization of human topoisomerase IIIalpha during the cell cycle progression in PHA-activated peripheral blood lymphocytes and HL-60 leukemia cells. [D] . Lin, Chou-Wen. 1999

机译：在PHA激活的外周血淋巴细胞和HL-60白血病细胞的细胞周期进程中，人类拓扑异构酶IIIalpha的差异表达和核定位。
6. A dual efficacy-implementation trial of a novel mobile application for childhood nephrotic syndrome management: the UrApp for childhood nephrotic syndrome management pilot study protocol (UrApp pilot study) [O] . Chia-shi Wang, Cam Escoffery, Rachel E. Patzer, 2020

机译：用于儿童肾病综合征管理的新型移动应用程序的双重功效实施试验：用于儿童肾病综合征管理的UrApp试点研究方案（UrApp试点研究）
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Differential alteration in peripheral T-regulatory and T-effector cells with change in P-glycoprotein expression in Childhood Nephrotic Syndrome: A longitudinal study

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