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Suppression of proliferation, tumorigenicity and metastasis of lung cancer cells after their transduction by interferon-beta gene in baculovirus vector

机译:干扰素-β基因转导杆状病毒载体后对肺癌细胞增殖,致瘤性和转移的抑制

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摘要

Background: Gene therapy represents an interesting alternative treatment for cancers. Interferon-beta is well known as a multifunctional cytokine that provides antiviral, antiproliferative, antiangiogenic and immunomodulating effects. For this reason introduction of this cytokine gene in baculovirus vector is seen as a rather promising tool for anticancer therapy.
机译:背景:基因疗法代表了一种有趣的癌症替代疗法。干扰素-β是众所周知的多功能细胞因子,具有抗病毒,抗增殖,抗血管生成和免疫调节作用。因此,在杆状病毒载体中引入该细胞因子基因被认为是抗癌治疗的相当有前途的工具。

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