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首页> 外文期刊>Cytokine >Serum IL-9, IL-17, and TGF-beta levels in subjects with diabetic kidney disease (CURES-134)
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Serum IL-9, IL-17, and TGF-beta levels in subjects with diabetic kidney disease (CURES-134)

机译：糖尿病肾病患者的血清IL-9，IL-17和TGF-β水平（CURES-134）

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摘要

The role of inflammation in both diabetes and diabetic kidney disease (DKD) is becoming more widely accepted. However, the role of recently characterized T cell cytokines interleukin (IL)-9 and IL-17 in diabetes and especially DKD is less well studied. Transforming growth factor beta (TGF-beta) controls the secretion of both of these cytokines. In this study, we estimated the levels of IL-9, IL-17, and TGF-beta in the serum of subjects with normal glucose tolerance (NGT = 88) and subjects with type 2 diabetes without (diabetes mellitus (DM) = 65) and with DKD (DKD = 97) using enzyme-linked immunosorbent assay (ELISA), and we correlated these levels with the clinical risk factors of diabetes and DKD. IL-17 levels showed a serial decline and TGF-beta levels showed a serial increase from NGT to DM to DKD (p < 0.001). However, the IL-9 levels were significantly reduced in the DM group compared to the NGT and DKD group (p < 0.001). While TGF-beta and IL-17 showed a positive and negative correlation, respectively, with fasting and postprandial glucose levels and glycated hemoglobin (HbA1c), IL-9 showed positive correlation with urea and microalbuminuria. Apart from pro-inflammatory cytokines, T helper (Th) cytokines might play an important role in insulin resistance and DKD. (C) 2014 Elsevier Ltd. All rights reserved.
机译：炎症在糖尿病和糖尿病肾病（DKD）中的作用已被越来越广泛地接受。但是，最近表征的T细胞细胞因子白介素（IL）-9和IL-17在糖尿病尤其是DKD中的作用尚未得到很好的研究。转化生长因子beta（TGF-beta）控制这两种细胞因子的分泌。在这项研究中，我们估计了葡萄糖耐量正常（NGT = 88）和无糖尿病（DM）= 2的2型糖尿病患者血清中IL-9，IL-17和TGF-β的水平。 ）以及使用酶联免疫吸附测定（ELISA）的DKD（DKD = 97），我们将这些水平与糖尿病和DKD的临床危险因素相关联。从NGT到DM再到DKD，IL-17水平显示出连续下降，TGF-β水平显示出连续上升（p <0.001）。但是，与NGT和DKD组相比，DM组的IL-9水平显着降低（p <0.001）。 TGF-beta和IL-17分别与禁食和餐后葡萄糖水平和糖化血红蛋白（HbA1c）呈正相关和负相关，而IL-9与尿素和微量白蛋白尿呈正相关。除促炎细胞因子外，T辅助（Th）细胞因子可能在胰岛素抵抗和DKD中起重要作用。 （C）2014 Elsevier Ltd.保留所有权利。

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