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T helper 2 (Th2) cell differentiation, type 2 innate lymphoid cell (ILC2) development and regulation of interleukin-4 (IL-4) and IL-13 production

机译：T辅助2（Th2）细胞分化，2型先天淋巴样细胞（ILC2）发育以及白介素4（IL-4）和IL-13产生的调节

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摘要

Interleukin-4 (IL-4), IL-5 and IL-13, the signature cytokines that are produced during type 2 immune responses, are critical for protective immunity against infections of extracellular parasites and are responsible for asthma and many other allergic inflammatory diseases. Although many immune cell types within the myeloid lineage compartment including basophils, eosinophils and mast cells are capable of producing at least one of these cytokines, the production of these "type 2 immune response-related" cytokines by lymphoid lineages, CD4 T helper 2 (Th2) cells and type 2 innate lymphoid cells (ILC2s) in particular, are the central events during type 2 immune responses. In this review, I will focus on the signaling pathways and key molecules that determine the differentiation of naive CD4 T cells into Th2 cells, and how the expression of Th2 cytokines, especially IL-4 and IL-13, is regulated in Th2 cells. The similarities and differences in the differentiation of Th2 cells, IL-4-producing T follicular helper (Tfh) cells and ILC2s as well as their relationships will also be discussed. Published by Elsevier Ltd.
机译：白细胞介素4（IL-4），IL-5和IL-13是2型免疫反应期间产生的标志性细胞因子，对于抵抗细胞外寄生虫感染的保护性免疫至关重要，并导致哮喘和许多其他过敏性炎症。尽管骨髓谱系区隔中的许多免疫细胞类型（包括嗜碱性粒细胞，嗜酸性粒细胞和肥大细胞）都能产生至少一种这些细胞因子，但淋巴样谱系，CD4 T辅助细胞2会产生这些“与2型免疫应答相关”的细胞因子。 Th2）细胞和2型先天淋巴样细胞（ILC2）特别是2型免疫应答过程中的中心事件。在这篇综述中，我将重点介绍确定原始CD4 T细胞向Th2细胞分化的信号通路和关键分子，以及Th2细胞中Th2细胞因子（尤其是IL-4和IL-13）的表达如何受到调控。还将讨论Th2细胞，产生IL-4的T卵泡辅助细胞（Tfh）和ILC2s分化的异同及其关系。由Elsevier Ltd.发布

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