• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cytokine >Cytokine profile in the synovial fluid of patients with temporomandibular joint disorders: A systematic review
【24h】

Cytokine profile in the synovial fluid of patients with temporomandibular joint disorders: A systematic review

机译：颞下颌关节疾病患者滑液中的细胞因子谱：系统评价

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The aim of this study was to review the cytokine profiles in the synovial fluid (SF) of patients with ternporomandibular joint disorders (TMJD). Databases were searched from 1965 till September 2015 using different combinations of the following key words: "Temporomandibular joint"; "Cytokine"; "disorder"; and "synovial fluid" and "inflammation". Titles and abstracts of studies identified using the above-described protocol were screened and checked for agreement. Full-texts of articles judged by title and abstract to be relevant were read and independently evaluated. Hand-searching of the reference lists of potentially relevant original and review articles was also performed. The pattern of the present systematic review was customized to mainly summarize the relevant data. Fifteen studies were included. In 12 studies, cytokine profile of patients with TMJD was assessed using enzyme linked immunosorbent assay; and in 2 studies, histological analysis was performed to assess the cytokine profile of patients with TMJD. Patients with TMJD presented raised levels of interleukin (IL)-6 in 8 studies, IL-1 beta (1 beta) in 5 studies and tumor necrosis factor-alpha (TNF-alpha) in 5 studies. Two studies showed no significant difference in TNF-alpha levels in patients with and without TMJD; and IL-1 beta levels were comparable in patients with and without TMJD in 2 studies. Raised levels of IL-6, TNF-alpha, IL-1 beta, IL-8, and IFN-gamma in the SF have been associated with inflammation in patients with TMJD. Cytokines IL-10, osteoclastogenesis inhibitory factor/osteoprotegerin (OCIF/OPG), and VEGF found in the SF of TMJs could have an anti-inflammatory effect. (C) 2015 Elsevier Ltd. All rights reserved.
机译：这项研究的目的是审查患有眶下颌关节疾病（TMJD）的患者滑液（SF）中的细胞因子谱。从1965年至2015年9月，使用以下关键词的不同组合搜索数据库：“颞下颌关节”; “细胞因子”; “紊乱”;和“滑液”和“发炎”。筛选使用上述方案鉴定的研究的标题和摘要，并检查是否一致。阅读标题和摘要判断为相关的文章全文，并进行独立评估。还手动搜索了可能相关的原始文章和评论文章的参考列表。本系统综述的模式是定制的，主要用于汇总相关数据。包括十五项研究。在12项研究中，使用酶联免疫吸附测定法评估了TMJD患者的细胞因子谱。在2项研究中，进行了组织学分析以评估TMJD患者的细胞因子谱。 TMJD患者的8项研究显示白介素（IL）-6水平升高，5项研究显示IL-1 beta（1 beta）升高，5项研究显示肿瘤坏死因子-α（TNF-alpha）升高。两项研究表明，有或没有TMJD的患者，TNF-α水平无显着差异。在2项研究中，有或没有TMJD的患者中IL-1β水平相当。 SF中IL-6，TNF-α，IL-1β，IL-8和IFN-γ水平升高与TMJD患者的炎症有关。在TMJs的SF中发现的细胞因子IL-10，破骨细胞生成抑制因子/骨保护素（OCIF / OPG）和VEGF可能具有抗炎作用。 （C）2015 Elsevier Ltd.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号