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首页> 外文期刊>British journal of ophthalmology >Prevalence and characteristics of macular atrophy in eyes with neovascular age-related macular degeneration. A study from a long-term observational dataset: the Fight Retinal Blindness! project
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Prevalence and characteristics of macular atrophy in eyes with neovascular age-related macular degeneration. A study from a long-term observational dataset: the Fight Retinal Blindness! project

机译：新生心血管年龄相关黄斑变性眼光萎缩的患病率与特征。 长期观察数据集的研究：抗击视网膜失明！ 项目

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摘要

The alpha 1-adrenergic receptors activate a phospholipase C enzyme by coupling to members of the large molecular size (approximately 74 to 80 kilodaltons) G alpha h family of guanosine triphosphate (GTP)-binding proteins. Rat liver G alpha h is now shown to be a tissue transglutaminase type II (TGase II). The transglutaminase activity of rat liver TGase II expressed in COS-1 cells was inhibited by the nonhydrolyzable GTP analog guanosine 59-O-(3-thiotriphosphate) or by alpha 1-adrenergic receptor activation. Rat liver TGase II also mediated alpha 1-adrenergic receptor stimulation of phospholipase C activity. Thus, G alpha h represents a new class of GTP-binding proteins that participate in receptor signaling and may be a component of a complex regulatory network in which receptor-stimulated GTP binding switches the function of G alpha h from transglutamination to receptor signaling.
机译：α1-肾上腺素能受体通过与大分子大小（约74〜80千伏尔顿）GαHαHαHiphosphate（GTP） - 困扰蛋白的偶甲族的成员而激活磷脂酶C酶。 现在显示大鼠肝脏αHαH是组织转谷氨酰胺酶II型（TGase II）。 通过不可溶解的GTP类似物鸟苷59-O-（3-硫二磷酸）或通过α1-肾上腺素能受体活化抑制在COS-1细胞中表达的大鼠肝TGase II的转氨酰胺酶活性。 大鼠肝TGase II还介导的α1-肾上腺素能受体刺激磷脂酶C活性。 因此，GαH代表参与受体信号传导的新类GTP结合蛋白，并且可以是其中受体刺激的GTP结合将GαH与转谷聚集的功能转换为受体信号传导的复杂调节网络的组分。

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