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首页> 外文期刊>Cytokine >Soluble interleukin-2 receptor in stage I-III melanoma.
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Soluble interleukin-2 receptor in stage I-III melanoma.

机译：I-III期黑色素瘤中的可溶性白介素2受体。

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The aim of the present study was to assess the prognostic value of soluble interleukin-2 receptor (sIL-2R) serum levels in stage I-III melanoma patients. The levels of sIL-2R were determined using an enzyme immunometric test kit in 329 patients affected by malignant melanoma (MM) from 1995 to 2004. Correlations between sIL-2R values, baseline patients and tumour features were studied by contingency tables and the chi-square test. The Kaplan-Meier product limit method was applied to plot disease-free survival (DFS) curves. Univariate analysis was performed with the Log-rank test. Cox proportional-hazards regression was used to analyse the effect of several risk factors on DFS. In total, 2330 blood samples were collected during follow-up of 329 MM patients. Forty-five (13.7%) patients had Breslow tumour thickness1.00 and 2.00 and 4.00 mm. Ulceration was present in 64 cases (19.4%). Thirty-nine sentinel lymph nodes (SLNs) (11.8%) were infiltrated by MM. Soluble IL-2R values ranged from 130 to 1420 U/ml; median value was 500 U/ml. One hundred twenty-one (36.8%) patients presented with sIL-2R>600 U/ml at first measure (FM), 194 patients (58.9%) with values increasing up to or more than 600 U/ml [increasing values (IV) pattern]. A correlation was found between Breslow's tumour values and the IV sIL-2R pattern group (P=0.0304 with chi2 test). Gender, presence of ulceration, Breslow tumour thickness, FM and IV sIL-2R pattern groups had a significant prognostic value for DFS. At multivariate analysis, presence of ulceration, gender, FM and IV sIL-2R pattern groups emerged as independent prognostic factors for DFS. The 5-year DFS rate was 88% for patients with FM<600 U/ml and 76.9% for patients with FM>600 U/ml. In IV pattern, the 5-year DFS rate was 69.5% compared to 87% for patients with no sIL-2R values>600 U/ml during follow-up. sIL-2R values are associated with progression of MM. Further studies are needed to address the role of the IL-2/IL-2R/sIL-2R axis in melanoma biology.
机译：本研究的目的是评估I-III期黑色素瘤患者血清可溶性白介素2受体（sIL-2R）血清水平的预后价值。 1995年至2004年，通过酶联免疫试剂盒对329例受恶性黑色素瘤（MM）影响的患者确定了sIL-2R的水平。通过列联表和chi-方格测试。 Kaplan-Meier产品极限法用于绘制无病生存期（DFS）曲线。用对数秩检验进行单变量分析。使用Cox比例风险回归分析了几种风险因素对DFS的影响。在329例MM患者的随访期间，总共收集了2330份血液样本。 45名（13.7％）患者的Breslow肿瘤厚度<或= 1.00，83（25.2％）患者> 1.00和<或= 2.00 mm，72（21.9％）患者> 2.00和<或= 4.00 mm，47（ 14.3％）患者> 4.00毫米。溃疡有64例（19.4％）。 MM浸润了39个前哨淋巴结（SLN）（11.8％）。可溶性IL-2R值范围为130至1420 U / ml;中值是500U / ml。一百二十一（36.8％）的患者在sIL-2R> 600 U / ml时首次出现（FM），194例（58.9％）的值升高至或超过600 U / ml [升高值（IV ）模式]。发现Breslow的肿瘤值与IV sIL-2R模式组之间存在相关性（χ2检验，P = 0.0304）。性别，溃疡的存在，Breslow肿瘤的厚度，FM和IV sIL-2R模式组对DFS有重要的预后价值。在多变量分析中，溃疡，性别，FM和IV sIL-2R模式组的存在已成为DFS的独立预后因素。 FM <600 U / ml的患者的5年DFS率为88％，FM> 600 U / ml的患者的76.9％。在IV模式下，其5年DFS率为69.5％，而随访期间sIL-2R值> 600 U / ml的患者为87％。 sIL-2R值与MM进展有关。需要进一步的研究来解决IL-2 / IL-2R / sIL-2R轴在黑色素瘤生物学中的作用。

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