...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cytokine >The proinflammatory cytokines TNF-alpha and IL-1beta impair economy of contraction in human myocardium.
【24h】

The proinflammatory cytokines TNF-alpha and IL-1beta impair economy of contraction in human myocardium.

机译：促炎细胞因子TNF-α和IL-1β损害人心肌的收缩经济性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Considerable experimental evidence has accumulated over the past years that proinflammatory cytokines, especially TNF-alpha and IL-1beta, impair myocardial function in different animal species. On the other hand, several prospective clinical trials studying TNF-alpha antagonist in patients with chronic heart failure were not able to demonstrate a benefit. As there might be a relevant species-related discrepancy, we intended to prove our previous results demonstrating impaired myocardial economy after exogenous administration of recombinant TNF-alpha in rat myocardium. In the present study, both TNF-alpha and IL-1beta not only revealed an immediate negative inotropic effect but also increased specific oxygen demand in human right-atrial myocardium. Enhanced oxygen consumption was not caused by an elevated basal metabolism but an impaired economy of contraction. Our results suggest that proinflammatory cytokines have a considerable effect on myocardial mechano-energetic parameters in human myocardium as well.
机译：在过去的几年中，积累了大量实验证据，证明促炎细胞因子，尤其是TNF-α和IL-1beta，会损害不同动物物种的心肌功能。另一方面，一些针对慢性心力衰竭患者的TNF-α拮抗剂的前瞻性临床试验未能证明其益处。由于可能存在与物种有关的差异，我们打算证明我们先前的结果表明，在大鼠心肌中外源施用重组TNF-α后，心肌经济受损。在本研究中，TNF-α和IL-1beta不仅显示出即时的负性肌力作用，而且还增加了人右心房心肌的特定需氧量。耗氧量增加不是由基础代谢升高引起的，而是收缩经济的损害。我们的结果表明，促炎细胞因子对人心肌的心肌机械能参数也有相当大的影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号