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首页> 外文期刊>Cytokine >Elevated circulating inflammatory markers in female patients with cardiac syndrome X.
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Elevated circulating inflammatory markers in female patients with cardiac syndrome X.

机译：女性心脏综合征X患者的循环炎症标志物升高。

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Background. The pathophysiological mechanism in cardiac syndrome X has been suggested as impairment in normal endothelial function of the coronary microvasculature, resulting in inadequate flow reserve. However, despite the extensive studies, the precise mechanisms in cardiac syndrome X remain unclear. Purpose. The present study was, therefore, to investigate whether inflammatory cells and markers such as C-reactive protein (CRP) and interleukin-6 (IL-6) might be involved in the pathogenesis of cardiac syndrome X. Methods. Thirty-six female patients with cardiac syndrome X and 30 sex-matched normal controls were prospectively enrolled in this study. Blood samples were drawn for measuring white blood and monocyte cells, inflammatory markers such as CRP and IL-6, and data were compared between patients with cardiac syndrome X and normal controls. Results. The data showed that increased numbers of white blood and monocyte cells were found in patients with cardiac syndrome X compared with normal controls (white blood cells: 7072+/-1146/mm(3) vs. 6138+/-1079/mm(3); monocyte cells: 612+/-186/mm(3) vs. 539+/-190/mm(3)p<0.05, respectively). Moreover, patients with cardiac syndrome X were detected to have significantly higher plasma CRP and IL-6 levels in comparison with patients with normal controls (CRP: 0.48+/-0.26mg/L vs. 0.22+/-0.15mg/L; IL-6: 13.4+/-1.2pg/dl vs. 6.2+/-0.6pg/dl, p<0.01, respectively). The multivariate analysis showed that CRP was the independent variable most strongly associated with cardiac syndrome X. Conclusions. Our data suggested that low-grade, chronic inflammation might contribute to the development of cardiac syndrome X manifested by increased plasma levels of inflammatory cells and inflammatory markers.
机译：背景。心脏综合征X的病理生理机制被认为是冠状微血管正常内皮功能的损害，导致血流储备不足。然而，尽管进行了广泛的研究，心脏综合征X的确切机制仍不清楚。目的。因此，本研究旨在调查炎症细胞和C反应蛋白（CRP）和白介素6（IL-6）等标记物是否可能参与X综合征的发病。前瞻性招募了三十六名患有心脏综合征X的女性患者和30名性别匹配的正常对照。抽取血液样本以测量白血球和单核细胞，炎性标志物（例如CRP和IL-6），并比较X型心脏综合征患者和正常对照组的数据。结果。数据显示，与正常对照组相比，患有X型心脏病综合征的患者发现白血球和单核细胞数量增加（白血球：7072 +/- 1146 / mm（3）与6138 +/- 1079 / mm（3 ）;单核细胞：612 +/- 186 / mm（3）与539 +/- 190 / mm（3）p <0.05分别）。此外，与正常对照组相比，检测到患有X综合征的心脏病患者的血浆CRP和IL-6水平明显更高（CRP：0.48 +/- 0.26mg / L vs. 0.22 +/- 0.15mg / L; IL -6：13.4 +/- 1.2pg / dl与6.2 +/- 0.6pg / dl，p <0.01）。多元分析表明，CRP是与X综合征最相关的独立变量。结论。我们的数据表明，低度，慢性炎症可能会导致心脏综合征X的发展，其表现为炎症细胞和炎症标志物的血浆水平升高。

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