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首页> 外文期刊>Cytokine >Specificity of immunomodulator secretion in urinary samples in response to infection by alpha-hemolysin and CNF1 bearing uropathogenic Escherichia coli.
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Specificity of immunomodulator secretion in urinary samples in response to infection by alpha-hemolysin and CNF1 bearing uropathogenic Escherichia coli.

机译：尿液样品中免疫调节剂分泌的特异性，以响应由α-溶血素和携带尿毒症性大肠杆菌的CNF1感染。

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摘要

Escherichia coli are the most common etiological agents of urinary tract infections (UTIs). Uropathogenic E. coli (UPECs) produce specific toxins including the cytotoxic necrotizing factor-1 (CNF1) and the alpha-hemolysin (alpha-Hly). CNF1 triggers, through Rho protein activation, a specific gene response of host cells, which results in the production for instance of interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1) and the macrophage inflammatory protein-3alpha (MIP-3alpha). The alpha hemolysin alpha-Hly also triggers the production of inflammatory mediators. Cnf1 is always associated with alpha-hly in a pathogenicity island conserved among UPECs. Using two complementary approaches we have investigated whether alpha-hly and cnf1 bearing UPECs are associated with a specific type of UTI both in term of pathology and host response. Here we report that UPECs bearing alpha-hly/cnf1 have a prevalence of 50% in UPECs isolated from hemorrhagic UTIs, as compared to 30% in the overall UPEC population. In addition, we observed that MCP-1, and IL-8 to a lower extent, is produced in urine at higher concentrations in UTIs caused by UPECs carrying alpha-hly/cnf1.
机译：大肠杆菌是尿路感染（UTI）的最常见病原体。致病性大肠杆菌（UPEC）产生特定的毒素，包括细胞毒性坏死因子-1（CNF1）和α-溶血素（alpha-Hly）。 CNF1通过Rho蛋白激活触发宿主细胞的特定基因应答，从而导致产生白介素8（IL-8），单核细胞趋化蛋白1（MCP-1）和巨噬细胞炎性蛋白3alpha。 （MIP-3alpha）。 α溶血素α-Hly也触发炎性介质的产生。 Cnf1始终与UPEC中保守的致病岛中的alpha-hly相关。使用两种互补的方法，我们研究了携带α-hly和cnf1的UPEC在病理学和宿主反应方面是否与特定类型的UTI相关。在这里，我们报告携带α-hly/ cnf1的UPEC在从出血性UTI分离出的UPEC中的患病率为50％，而在整个UPEC人群中的患病率为30％。另外，我们观察到尿液中尿中MCP-1和IL-8的含量较低，这是由携带α-hly/ cnf1的UPEC引起的。

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